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Tromboendarterectomia pulmonar: tratamiento de elección para la hipertensión pulmonar tromboembólica crónica 18 a?os de seguimiento del Hospital Universitario Fundación Favaloro

Keywords: pulmonary hypertension, pulmonary thromboendarterectomy, pulmonary thromboembolism, chronic thromboembolic pulmonary hypertension, right ventricle.

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Abstract:

pulmonary thromboendarterectomy is the treatment of choice for patients with chronic thromboembolic pulmonary hypertension. objective: to report our 18-years experience in pulmonary thromboendarterectomy. material and methods: forty one patients were analyzed between november/1992 and august/2010. inclusion criteria: mean pulmonary artery pressure (papm) >30 mmhg and pulmonary vascular resistance (pvr) >300 dinas/sec.cm-5. pulmonary angiography determined the surgical feasibility. survival was calculated using the kaplan-meier method and to compare the 2 groups log rank test. results: forty four percent of the patients were classified in class iv. the hemodynamic changes after pulmonary thromboendarterectomy were significant (p < 0.001). papm 53 ± 2 vs. 29 ± 2 mm hg, pvr 857 ± 65 vs. 245 ± 25 dinas/sec. cm-5 and ci 2.3 ± 0.1 vs. 3 ± 0.1. in-hospital mortality was 15%; in classes ii - iii was 4%, and in class iv 33% (p = 0.01). late mortality was 12%. ninety three percent of the patients improved their functional class. overall survival at 1, 2, 5 and 10 years was 85%, 82%, 75% and 71% respectively. survival according to functional class showed significant differences (p = 0.02). conclusion: in our experience pulmonary thromboendarterectomy showed benefits even in this high risk population.

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