1H AND 13C NMR SPECTRAL ASSIGNMENTS AND X-RAY CRYSTALLOGRAPHY OF 4,5,8,12b-TETRAHYDRO-ISOINDOLO[1,2 -α ]ISOQUINOLINE AND DERIVATIVES

12b-hydroxy-5,6,8,12b-tetrahydroisoindolo[1,2-α] isoquinolin-8-one (4), 5,6,8,12b-tetrahydroisoindolo[1,2-α]isoquinoline (5) and 12b-hydroxy-5,6,8,12b-tetrahydroisoindolo[1,2-α]isoquinoline (6) were obtained by reduction of 4,5,8,12b-tetrahydroisoindolo[1,2-α]isoquinolin-8-one (3) with lialh4/thf/n2. the precursor and products were characterized by nmr spectroscopy and the x-ray crystal structure of 5 hydrochloride monohydrate (5a) was determined. 1h and 13c nmr spectra were completely assigned for compounds 3, 4, and 5a, using two-dimensional experiments (h-h cosy, hmqc, hmbc and h-h noesy).