COMPARATIVE STUDIES OF LEWIS ACIDITY OF ALKYL-TIN CHLORIDES IN MULTICOMPONENT BIGINELLI CONDENSATION USING GRINDSTONE CHEMISTRY TECHNIQUE

a simple and efficient procedure for the one pot biginelli condensation reaction of aldehydes, a-ketoester and urea employing sncl4.5h2o /mono/di/tri-butyl- tin chloride as a novel catalyst is described. compared to classical biginelli reaction conditions, the present method has the advantages of good yields, short reaction times and experimental simplicity. further, comparative efficiency of alkyl- tin chlorides in multicomponent biginelli condensation reaction is also studied under solvent free conditions.