SYNTHESIS AND IN-VITRO STUDY OF SOME MEDICINALLY IMPORTANT MANNICH BASES DERIVED FROM 2-AMINO-9 [{(1, 3 DIHYDROXY PROPANE-2YL) OXY} METHYL] 6-9 DIHYDRO-3H-PURIN-6-ONE

a series of biologically active mannich bases with heteroaromatic ring system have been synthesized employing mannich reaction of 2-amino-9 [{(1,3 dihydroxy propane-2yl) oxy}methyl] 6-9 dihydro-3h-purin-6-one ( potent drug) with biologically active sulphonamides and secondary amines. they were analyzed by elemental analysis and characterized by spectral studies- uv, ir, 1h nmr, powder x-ray diffraction and scanning electron microscopy. the mannich bases were screened for their antibacterial activity against various gram + and gram - bacteria. the results had shown that the mannich bases are quiet active against pathogens under study at varying concentrations. the toxicity of synthesized mannich bases was ascertained by ld50 test.