NEW APPROACHES FOR THE SYNTHESIS OF HYDRAZONE DERIVATIVES AND THEIR ANTITUMOR EVALUATION

the hydrazide-hydrazone 3 reacted with benzenediazonium chloride to give the phenylhydrazone derivative 5. the latter underwent a series of hetero-cyclization reactions to give pyridazine, 1,2,3-triazole and pyrazole derivatives. the antitumor evaluation of the newly synthesized products against the three cancer cells lines namely breast adenocarcinoma (mcf-7), non-small cell lung cancer (nci-h460) and cns cancer (sf-268) showed that some of them have higher inhibitory effects towards the three cell lines compared to the standard.