Study on inclusion interaction of ibuprofen with Β-cyclodextrin derivatives

the inclusion interaction of ibuprofen with hydroxypropyl-β-cyclodextrin (hp-β-cd), hydroxyethyl-β-cyclodextrin (he-β-cd) and methyl-β-cyclodextrin (me-β-cd) was investigated by fluorescence spectroscopy. experimental conditions affecting the inclusion process, such as host molecule, hp-β-cd concentration and ph, were discussed in detail. the results suggested the formation of inclusion complexes with a stoichiometric ratio of 1:1 and hp-β-cd was more suitable to include neutral ibuprofen molecule. in addition, a phase solubility study was performed by mixing an excess amount of ibuprofen with aqueous solution containing increasing amount of β-cds using uv-vis. the results indicated that the solubility of ibuprofen was increased by inclusion with β-cd derivatives, and hp-β-cd was most efficient among the three β-cd derivatives. moreover, stable solid inclusion complexes were established and characterized by dsc.