Angiogénesis neoplásica

neoplastic angiogenesis is an essential process in the progressive growth of neoplasms and the production of metastasis. angiogenesis consists of a series of linked and sequential steps that ultimately leads to the development of a neovascular blood supply to the tumor mass. vegf has got an essential role in neoplastic angiogenesis, therefore it is an important target in the treatment of neoplasms. bevacizumab, a humanized monoclonal antibody, inhibits vegf, and may also improve the delivery of chemotherapy to the tumor mass. multi-kinase ihibitors (sorafenib and sunitinib) are orally administered small-molecules, that inhibit different receptors (essentials in the neoplastic angiogenesis), such as the vegfr or pdgfr. these agents are useful in the treatment of advanced renal-cell carcinoma, and are under investigation in several tumors.