Synthesis, growth and characterization of new 1,3,4 -thiadiazole-5-(n-substituted)-sulfonamides cristals

new 1,3,4-thiadiazole-5-(n-substituted)-sulfonamide derivatives incorporating n-cyclohexyl, n-benzyl and n-[sec-butyl] moieties, carbonic anhydrase inhibitors, have been obtained by an optimized synthesis. single crystals of these sulfonamides have been successfully grown up to suitable dimensions for x-ray diffraction measurements by slow evaporation of solvent at room temperature. structural data for these monoclinic compounds are compared with those of related phases. the sulfonyl moiety presents a distorted tetrahedral arrangement around the s atom. the different groups introduced cause no observable modifications of the 1,3,4-thiadiazole ring structure. thermal analysis show total sample degradation at temperatures higher than that of the melting point of the three phases. the ftir spectra confirm the compounds formation and provide a first insight on the modes of nh…n hydrogen bond in these sulfonamides.