Angiogénese e Arteriogénese na Doen？a Arterial Periférica

in adaptation to arterial obstruction and consequent ischemia, organisms induce the arteriogenic and angiogenic mechanisms in order to improve blood supply to tissues. however, 25% of the patients with peripheral arterial disease will have a deterioration of their condition, suggesting failure of the adaptative processes. these mechanisms are extremely complex, resulting from the interaction of multiple molecules suitably coordinated with specific cells. the study of interindividual variability in the molecules involved in the vascular adaptive mechanisms to ischemia could probably enable the identification of prognostic biomarkers not only for the disease evolution, but also for the response to therapeutic approaches.