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La etiología de la esquizofreniaKeywords: schizophrenia, genetics, genome, etiology, snp, cnv, polygenic, gwas, epidemiology. Abstract: research conducted in recent years represents a new dawn of knowledge for the risk factors of schizophrenia, and genome-wide approaches have revolutionized the field of genetic mapping of schizophrenia. the aggregate genetic data increasingly support a combination of rare and common genetic variation in schizophrenia, a major role for polygenic inheritance, and a genetic overlap (pleiotropy) of schizophrenia and other psychiatric disorders, such as bipolar disorder and autism. a main challenge for the field is the translation of established genetic associations into a better pathophysiological understanding of schizophrenia. the current and upcoming resequencing programs - both exomes (all exons) and full genomes - and genome-wide transcriptional analyses will allow a more thorough dissection of the molecular genetics of the disorder.
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