COMPARACIóN DE CUATRO PROGRAMAS UTILIZADOS EN LA DETERMINACIóN DE LA COMPOSICIóN GENéTICA ANCESTRAL DE LA POBLACIóN ANTIOQUE？A

the genetic structure of the population of antioquia is complex and arises from the historical admixture of european, african and amerindian populations. the genetic makeup of 849 antioquian individuals was determined using a set of 75 ancestry informative markers and four computer programs based on bayesian methods in order to infer the composition of ancestral admixture. a great european component (60%) was twice as high as the amerindian contribution (28%), both with broad distributions, followed by a smaller african contribution (12%). the average number of generations since the admixture event was 11 generations per 100 cm, which makes this population a useful resource to implement admixture mapping studies. the usefulness of the marker set as well as the power and helpfulness of the computer programs were assessed.