Evolu？？o temporal da prolifera？？o neointimal após implante de dois tipos de stent farmacológico com polímeros biodegradáveis em modelo porcino: avalia？？o qualitativa por tomografia de coerência óptica sequencial

background: based on the hypothesis that the neointima found in drug-eluting stents (des) with biodegradable polymers at 28 days is not a definitive neointima and that optical coherence tomography (oct) is an effective method for sequential neointimal evaluation, we aim, in this experimental study, to compare oct findings at 28 and 90 days, in two different des with biodegradable polymers: the sirolimus-eluting stent (inspiron？, scitech) and the biolimus a9-eluting stent (biomatrix？, biosensors international). methods: overall, 6 non-atherosclerotic pigs were submitted to the implantation of 6 inspiron？ stents and 6 biomatrix？ stents. each pig received both stent types, one in each coronary artery (left anterior descending artery and circumflex artery) and after 28 and 90 days qualitative in-stent oct analyses were performed at 1-millimeter intervals. results: qualitative assessment was performed in-stent pairing millimeter by millimeter. heterogeneous neointimal tissue was evidenced in 39% at 28 days and in 0% at 90 days, the presence of intraluminal tissue in 18% at 28 days and in 0% at 90 days, luminal irregularity in 62% at 28 days and in 2% at 90 days (p < 0.005). there was no difference between groups regarding the quality of the neointima over time (p > 0.05). conclusions: the oct findings corroborate the hypothesis that the neointima found in des with biodegradable polymers at 28 days is not a definitive neointima. the most significant experimental evidence is the change in the neointimal characteristics observed at sequential oct.