El nuevo paradigma de la hemocromatosis neonatal: hepatitis fetal aloinmunitaria

the classical model of neonatal hemochromatosis was based on the analogy with hereditary hemochromatosis. medical treatment consisted on the antioxidant-chelator cocktail. the new hypothesis of an alloimmune origin of the process by which the pregnant woman mounts an igg-based destructive response against fetal hepatocytes offers a pathogenic explanation, allowing treatment to be focused on the immunological aspects, with excellent results, and opens the possibility of preventive treatment in future pregnancies. this new paradigm produces a deep impact in diagnosis, prognosis and treatment of the disease, that should be called "fetal alloimmune hepatitis".