Modificaciones en los marcadores enzimáticos hepáticos promovidos por veneno de ejemplares jóvenes de crotalus DURISSUS CUMANENSIS

to determinate the effect of the venom of young crotalus durissus cumanensis on levels of alt, ast and ap, balb/c mice were inoculated intraperitoneal with 0,75 mg/kg of purified venom. serum samples were obtained at different post-injection intervals (1, 3, 6, 12, 24h) and serum levels of alt, ast and ap were determined. a significative difference (p ？0,01) was observed in serum levels of alt at 6h and at 24h post-venom injection, with a maximum of 587,64 u/l at 24 h, when compared with controls. in addition, ast shows a significative elevation between 1h and 12h post venom injection, with a maximum level of 2327 u/l at 3 h, while ap only showed significant differences at 24 h post-venom injection. these results suggest that the venom of young crotalus durissus cumanensis induced liver-biliar injury, with a possible effect on skeletal muscle and/ or cardiac tissue.