Perfil dos horm？nios da tireoide em pacientes com cancer de mama em estado de menopausa

objective: the aim of this study was to determine thyroid hormone (th) profile in postmenopausal patients with breast cancer (bc). subjects and methods: 12 cam patients stages i or ii, without interventions that could interfere with tumor progression were selected, as well as and a control group with 18 postmenopausal women without cam. we measured serum anti-thyroperoxidase antibody (tpoab), thyroid-stimulating hormone (tsh), free thyroxine (t4l), estradiol (e2), follicle-stimulating hormone (fsh), and luteinizing hormone (lh), before and after surgery, besides immunohistochemistry for estrogen (er) and progesterone (pr) receptors. results: four patients with cam showed changes in thyroid hormone profile: two had hyperthyroidism, one hypothyroidism, and one was positive for tpo-ab. all of them positive for er and pr. tsh levels in breast cancer patients were not different from levels found in the control group (1.89 ± 1.56 vs. 2.86 ± 3.12 miu/ml), but the levels of t4l in patients with cam were statistically higher than those of the control group (1.83 ± 0.57 vs. 1.10 ± 0.20 ng/dl). conclusion: these results reinforce the need for assessment of thyroid status in cam patients, since in the absence of e2, changes in clinical hts can act in e2-controlled processes.