Pathological findings in fetuses of goats and cattle poisoned by Sida carpinifolia (Malvaceae)

in brazil, the consumption of sida carpinifolia by livestock has been associated with neurological diseases linked to lysosomal storage disorders. this paper describes the pathological findings in two caprine fetuses from dams that were experimentally poisoned with s. carpinifolia. the goats were orally dosed with 10 and 13g/kg of a paste of green chopped s. carpinifolia for 30 days and were observed for an additional 15 days period after the last dosage with the plant; thereafter they were euthanized and necropsied. the dams showed only slight clinical signs. the study also includes the findings in one bovine fetus from a naturally s. carpinifolia poisoned cow which showed mild incoordination, generalized tremors, staggering, and frequent falls. the cow was euthanized and necropsied. while there were no significant histopathological changes in the goats, in the cow vacuolation of purkinje neurons of the cerebellum, pancreatic acinar cells, and thyroid follicular cells were observed. the main microscopic changes observed in the caprine and bovine fetuses were vacuolation in the epithelium of renal tubules, thyroid follicular cells, and purkinje neurons of the cerebellum. transmission electron microscopy of sections from cns of the cow and its fetus revealed vacuoles containing fine granular material surrounded by membrane. lectin-histochemistry of cns sections from goat fetuses marked lightly to swga lectins, wga, and con-a.