Aspectos anatomopatológicos da leptospirose em c？es: 53 casos (1965-2011)

the pathological aspects of canine leptospirosis were studied in 53 dogs with a conclusive diagnosis of the disease, as confirmed by immunohistochemistry on renal tissue. main necropsy lesions included icterus (79.2%) and hemorrhage (75.5%), mainly in the lungs (56.6%). gross hepatic (56.6%) and renal (50.9%) changes were frequently found and were characterized mainly by discoloration (respectively 30.2% and 32.1%), accentuation of hepatic lobular pattern (26.4%) and white streaks in the cut surface of kidneys (22.6%). extrarenal lesions secondary to uremia occurred in half of the cases (50.9%). enlarged livers (11.3%), and kidneys (9.4%), and rough renal capsular surfaces (3.8%) were less common findings. in the histopathology of the kidneys (n=53), the encountered lesions (98.1%) were almost exclusively acute or subacute (96.2%) and were characterized by varying degrees of tubular nephrosis (86.8%) and non-suppurative interstitial nephritis (60.4%), with evident degenerative-inflammatory dissociation. in the histopathology of the liver (n=42), the encountered lesions (97.6%) consisted mainly of hepatocellular dissociation (78.6%), intracanalicular cholestasis (33.3%) and hepatocellular necrosis (31%). reactive lesions, such as kupffer cell hypertrophy, sinusoidal leucocytostasis and inflammatory mononuclear infiltrate within portal triads were observed in several cases (42.8%). in the histopathology of the lung (n=28), alveolar hemorrhage (85.7%) and edema (57.1%) were rather frequent lesions. neutrophils and macrophages in the alveolar spaces (35.7%) and neutrophils within small pulmonary vessels (17.9%) were also frequent findings. the findings stemming from the current study should serve as an alert for brazilian veterinary pathologists, since the pathological presentations of canine leptospirosis in this region (central region of the state of rio grande do sul, brazil) did not change in the last 50 years, and is still similar to that described worldwide up to