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EEA^%Uۆ:} "iN95϶p/9eWs?1R|'檧YEZb$ UIbuR~ 0+ endstream endobj 27 0 obj <>stream H\j >wٜ%PrNReby6l*s)do݀@q;@ڂ.]bqi"w8=8YWȁf8}ކ3aK txg^삠+v!a{Bhk 5YliFe̓T?}YV-ަxBm̒N(}H)&,#o0 endstream endobj 28 0 obj <>stream hެmK0ǿʽTM҂ ً؅.е#}{ӬnV@@G8 )4{) h וCÇhz1~3:qQ ]h~e>ƺR)j\)v bxD !m MFMá~Ϧ&!>stream hތVo6w "%$H-fAJBZK/I)6C&:{|;[Y%&ÐҘ,19si0W\ {i3-KiTy$ N3Xr`JXIe; Y~yc&PS==!h4x`0Ii:Ŋ'ŊN/O4&8NRjaGU瓫jj@ar]7,\"Onfllo_6M\v]r zw[|o<wuToٔųWk| QhJHV7  [sxG]co * |)8z73X3kx/a1_p-$vO%d^K^lLec<9Σ>Hv.q#IL믿+A(/Ws2-n˦'ڈp+>m py @Z&`1uk]ݩ ݝ9]:2Ae1iU#1bb,*AO>z4Mt"nK!rK{M/ Ed?!Afq~GSc&\;ѐM^)`7r_ &XH>G7}6VP԰܉Zv[k.@y>$|Y쓐ÉRE˧\Zml ܥq԰@݉\g`Ϲ_rώ[!>,d&@Y1ءw7wC|{:7κ˾RlkI57Ļ&ȇrg+]Ox^+7}#J BpǕuf|MTu|f"tlj%A?K8YbNazlnI' w endstream endobj 30 0 obj <>stream 2017-02-04T14:08:23+08:00 2017-02-04T14:08:20+08:00 2017-02-04T14:08:23+08:00 Acrobat PDFMaker 11 Word 版 uuid:f83687b4-65ac-4f37-aa6e-20b6c7851898 uuid:7ad59590-2870-41f3-b0e6-fa46ac5baea1 426 application/pdf Correlation between Sequencing Results from Liquid Plasma and Dried Plasma Spot (DPS) for Determination of HIV Type 1 Non-B Subtypes Background: The blotting paper is an alternative to the collection of blood in the tubes for analysis, especially in the field of Human Immunodeficiency Virus infection. This technique allows to easily send the collected samples to specialized laboratories while limiting the stresses of storage and transport. Objective: The objective of this study was to compare the results of sequencing performed on liquid plasma and Dried Plasma Spot (DPS) for the variants of HIV-1 non-B. Methodology: Fifty subjects diagnosed positive for HIV Type 1 using the Rapid Screening Tests voluntarily participated in this study. Two hundred microliters of plasma are deposited on blotting paper Whatman 903 and 500 μl in a micro tube. RNA was extracted from 140 µl of plasma fluid and from a piece of DPS of 5 mm of diameter using the QIAamp RNA Mini Kit QIAGEN®. After extraction, the Viral Load (VL) was performed on each sample of liquid plasma. A Reverse Transcription PCR and Nested PCR were used to amplify the regions of interest on the Protease and Reverse Transcriptase for subsequent sequencing. Results: Protease and Reverse Transcriptase were amplified and sequenced respectively for 44 (88%) and 48 (96%) with the liquid plasma samples and 40 (80%) and 45 (90%) with the DPS. The results of Viral Loads were in the range of 2.5 log10 and 6.5 log10. The results of sequencing are comparable for plasma samples and DPS. The correlation coefficient (R2) between the two methods is good (R2 = 0.903, p < 0.001). Conclusion: Liquid Plasma and Dried Plasma Spot give highly correlated results for sequencing strains of HIV type 1 non-B. Erick Ntambwe Kamangu, Adawaye Chatté, Dolores Vaira, Patrick de Mol, Georges Lelo Mvumbi, Richard Lunganza Kalala, Marie-Pierre Hayette Adobe PDF Library 11.0 Sequencing, Liquid Plasma, Dried Plasma Spot, HIV-1 Non-B, Kinshasa D:20170204060800 Background: The blotting paper is an alternative to the collection of blood in the tubes for analysis, especially in the field of Human Immunodeficiency Virus infection. This technique allows to easily send the collected samples to specialized laboratories while limiting the stresses of storage and transport. Objective: The objective of this study was to compare the results of sequencing performed on liquid plasma and Dried Plasma Spot (DPS) for the variants of HIV-1 non-B. Methodology: Fifty subjects diagnosed positive for HIV Type 1 using the Rapid Screening Tests voluntarily participated in this study. Two hundred microliters of plasma are deposited on blotting paper Whatman 903 and 500 μl in a micro tube. RNA was extracted from 140 µl of plasma fluid and from a piece of DPS of 5 mm of diameter using the QIAamp RNA Mini Kit QIAGEN®. After extraction, the Viral Load (VL) was performed on each sample of liquid plasma. A Reverse Transcription PCR and Nested PCR were used to amplify the regions of interest on the Protease and Reverse Transcriptase for subsequent sequencing. Results: Protease and Reverse Transcriptase were amplified and sequenced respectively for 44 (88%) and 48 (96%) with the liquid plasma samples and 40 (80%) and 45 (90%) with the DPS. The results of Viral Loads were in the range of 2.5 log10 and 6.5 log10. The results of sequencing are comparable for plasma samples and DPS. The correlation coefficient (R2) between the two methods is good (R2 = 0.903, p < 0.001). 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