Efecto de la suplementación con Vimang？ sobre indicadores de estrés oxidativo en jóvenes con diabetes mellitus tipo 1

introduction: the oxidative stress plays a fundamental role in the pathogenesis of diabetes mellitus complications. vimang？ (a natural antioxidant product) has been successfully used diseases characterized by an increase of oxidative stress. objective: to assess the effect of vimang？ on the redox state in young people presenting with type 1 diabetes mellitus. methods: a phase ii clinical, randomized, controlled unicenter trial to assess the antioxidant effectiveness tablets vimang？ in young people with type 1 diabetes mellitus including 50 patients located into two groups (25 each) who received 300 mg tablets vimang？ every eight hours and placebo, respectively was carried out. the glycemia control was assessed by glycosylated hemoglobin, a complete lipidic profile and hemochemical determinations were carried out. the variables of damage due to oxidative stress were assessed: peroxidation potential, total hydroperoxides, advanced products of the protein oxidation, malonylaldehyde and the reduced glutathione endogenous antioxidant. determinations were made before and at 3 months of intervention. groups were compared each other, in the two times as well as in an internally regarding the basal state previous to supplementation with vimang？ or placebo. results: the peroxidation potential increased at three months in both groups (p < 0,05), only decreased in the 25 % of the patients under supplementation. there was an increase of malonylaldehyde (p < 0,05), of total hydroperoxides (p < 0,01) and a also a decrease of reduced glutathione (p = 0,01) at three months in patients under treatment. it was neither related to supplementation nor to metabolic control, which improved in both groups. conclusions: vimang？ was not an effective antioxidant in the dose used in type 1 diabetes mellitus patients.