Paraganglioma of seminal vesicle and chromophobe renal cell carcinoma: a case report and literature review

context: extra-adrenal paragangliomas are rare tumors that have been reported in many locations, including the kidney, urethra, urinary bladder, prostate, spermatic cord, gallbladder, uterus and vagina. case report: this report describes, for the first time to the best of our knowledge, a primary paraganglioma of the seminal vesicle occurring in a 61-year-old male. the patient presented persistent arterial hypertension and a previous diagnosis of chromophobe renal cell carcinoma. it was hypothesized that the seminal vesicle tumor could be a metastasis from the chromophobe renal cell carcinoma. immunohistochemical characterization revealed expression of synaptophysin and chromogranin in tumor cell nests and peripheral s100 protein expression in sustentacular cells. succinate dehydrogenase a and b-related (sdha and sdhb) expression was present in both tumors. conclusions: no genetic alterations to the vhl and sdhb genes were detected in either the tumor tissue or tissues adjacent to the tumor, which led us to rule out a hereditary syndrome that could explain the association between paraganglioma and chromophobe renal cell carcinoma in a patient with arterial hypertension.