Systems of Progression in Transformation of Endothelial Proinflammatory Ischemia in Atherogenesis

Proinflammation attributes ischemic episodes with a series of progressive cellular transformations linking endothelial ischemic injury to a full range of events encompassing cellular degeneration and cell death. Ischemia induces endothelial activation in a process that promotes a subsequent phase of reperfusion injury that accompanies vasodilatation. Endothelial injury appears to activate initial changes in development of the atheromatous plaque and also is involved in subsequent progression towards evolving complicated plaques, including plaque rupture. One might envision endothelial injury as a series of initial activation steps inducing both inflammation and possibly also Ischemia to the tunica intima. Endothelial activation might be significant as a proinflammatory state in atherogenesis.