A 59 year-old woman with liver cirrhosis due to hepatitis C, complicated by refractory hepatic hydrothorax was treated with a TIPS (transjugular intrahepatic portosystemic shunt) procedure. The procedure was complicated by substantial gastrointestinal hemorrhage. EGD (esophagogastroduodenoscopy) was performed and revealed hemobilia. A hepatic angiogram was then performed revealing a fistulous tract between a branch of the hepatic artery and biliary tree. Bleeding was successfully stopped by embolization of the bleeding branch of the right hepatic artery. Hemobilia is a rare cause of upper gastrointestinal bleeding with an increasing incidence due to the widespread use of invasive hepatobiliary procedures. Hemobilia is an especially uncommon complication of TIPS procedures. We recommend that in cases of hemobilia after TIPS placement, a physician should immediately evaluate the bleeding to exclude an arterio-biliary fistula.
References
[1]
Sandblom, P. Latrogenic hemobilia. Am. J. Surg. 1986, 151, 754–758, doi:10.1016/0002-9610(86)90059-0.
[2]
Schouten van der Velden, A.P.; de Ruijter, W.M.; Janssen, C.M.; Schultze Kool, L.J.; Tan, E.C. Hemobilia as a late complication after blunt abdominal trauma: A case report and review of the literature. J. Emerg. Med. 2010, 39, 592–595, doi:10.1016/j.jemermed.2008.08.015.
[3]
Menzel, J.; Vestring, T.; Foerster, E.C.; Haag, K.; Roessle, M.; Domschke, W. Arterio-biliary fistula after transjugular intrahepatic portosystemic shunt: A life-threatening complication of the new technique for therapy of portal hypertension. Z. Gastroenterol. 1995, 33, 255–259. 7610693
[4]
D’Abrigeon, G.; Blanc, P.; Bauret, P.; Taourel, P.; Larrey, D.; Michel, H. Hemobilia of late disclosure after placement of transjugular intrahepatic portacaval shunt. Gastroenterol. Clin. Biol. 1993, 17, 513–514. 8243946
[5]
Rossle, M.; Siegerstetter, V.; Huber, M.; Ochs, A. The first decade of the transjugular intrahepatic portosystemic shunt (TIPS): State of the art. Liver 1998, 18, 73–89. 9588766
[6]
Rosch, J.; Keller, F.S. Transjugular intrahepatic portosystemic shunt: Present status, comparison with endoscopic therapy and shunt surgery, and future prospectives. World J. Surg. 2001, 25, 337–345. discussion 345–346., doi:10.1007/s002680020380.
[7]
Boyer, T.D.; Haskal, Z.J. The role of transjugular intrahepatic portosystemic shunt in the management of portal hypertension. Hepatology 2005, 41, 386–400, doi:10.1002/hep.20559. 15660434
Khan, R.; Sapkota, B.; Goldenberg, G.; Mansour, M.; Notar-Francesco, V.; Cerulli, M.A. Bleeding bile (hemobilia): An obscure cause of upper gastrointestinal bleeding: Case report and review of the literature. Practical Gastroenterol. 2010, 34, 36–43.
[11]
Sarr, M.G.; Kaufman, S.L.; Zuidema, G.D.; Cameron, J.L. Management of hemobilia associated with transhepatic internal biliary drainage catheters. Surgery 1984, 95, 603–607. 6710356
[12]
Cahow, C.E.; Burrell, M.; Greco, R. Hemobilia following percutaneous transhepatic cholangiography. Ann. Surg. 1977, 185, 235–241, doi:10.1097/00000658-197702000-00019.
[13]
Okuda, K.; Musha, H.; Nakajima, Y.; Takayasu, K.; Suzuki, Y.; Morita, M.; Yamasaki, T. Frequency of intrahepatic arteriovenous fistula as a sequela to percutaneous needle puncture of the liver. Gastroenterology 1978, 74, 1204–1207. 648810
[14]
Merrell, S.W.; Schnerder, P.D. Hemobilia—evolution of current diagnosis and treatment. West. J. Med. 1991, 155, 621–625. 1812632
[15]
Sabate, M.; Ibanez, L.; Perez, E.; Vidal, X.; Buti, M.; Xiol, X.; Mas, A.; Guarner, C.; Forne, M.; Sola, R.; et al. Paracetamol in therapeutic dosages and acute liver injury: Causality assessment in a prospective case series. BMC Gastroenterol. 2011, 11, doi:10.1186/1471-230X-11-80.
[16]
Hendren, W.H.; Warshaw, A.L.; Fleischli, D.J.; Bartlett, M.K. Traumatic hemobilia: Non-operative management with healing documented by serial angiography. Ann. Surg. 1971, 174, 991–993, doi:10.1097/00000658-197112000-00018. 5316207
[17]
Mizobata, Y.; Yokota, J.; Yajima, Y.; Sakashita, K. Two cases of blunt hepatic injury with active bleeding from the right inferior phrenic artery. J. Trauma 2000, 48, 1153–1155, doi:10.1097/00005373-200006000-00024.
[18]
Baker, A.R.; Corlett, S.K.; Cookson, J.B.; Carr-Locke, D.L. Hemobilia treated by nasobiliary catheterization. Am. J. Gastroenterol. 1987, 82, 783–785. 3605040
[19]
Yoshida, J.; Donahue, P.E.; Nyhus, L.M. Hemobilia: Review experience with a worldwide problem. Am. J. Gastroenterol. 1987, 82, 448–453. 3578223