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计算机科学技术学报 2010
Computational Cellular Dynamics Based on the Chemical Master Equation: A Challenge for Understanding ComplexityKeywords: biochemical networks,cellular signaling,epigenetics,master equation,nonlinear reactions,stochastic modeling Abstract: Modern molecular biology has always been a great source of inspiration for computational science. Half a century ago, the challenge from understanding macromolecular dynamics has led the way for computations to be part of the tool set to study molecular biology. Twenty-five years ago, the demand from genome science has inspired an entire generation of computer scientists with an interest in discrete mathematics to join the field that is now called bioinformatics. In this paper, we shall lay out a new mathem...
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