Synthesis, characterization and antimicrobial activity of some new pyrimidines containing tetrazole

In attempt to find new pharmacologically active molecules, we report here the synthesis and the in vitro antimicrobial activity of various new pyrimidines containing 5-phenyl tetrazole. The 3-(substituted phenyl) -1-(5-phenyl-1H-tetrazol-1-yl) prop-2-en-1-one[2a-f] were prepared by the reaction of 5-phenyl 1-acetyl tetrazole with different aromatic aldehydes in the presence of an alkaline medium. Reaction of [2a-f] with urea and thiourea resulted in 4-(substituted phenyl)-6-(5-phenyl-1H-tetrazol-1-yl)pyrimidin-2-ol [3a-f] and 4-(substituted phenyl)-6-(5-phenyl-1H-tetrazol-1-yl)pyrimidine-2-thiol [4a-f] respectively. The synthesized compounds were identified by spectral data and evaluated for their in vitro antibacterial and antifungal properties.