The therapeutic decision in the continuum nociceptive-neuropathic pain

Take that pain depends in each case on the transmembrane action potential (TAP) in nerve fibers, all drugs with anti-depolarizing, polarizing and combined anti-depolarizing and polarizing effects, can be considered potentially effective in pain and then "analgesics" regardless of the pathogenesis of pain (nociceptive or non-nociceptive-neuropathic).This explains why, in certain situations, it may be effective in analgesia drugs such as antidepressants, anticonvulsants, antiarrhythmics and antihypertensives (sometimes called "adjuvants") thatare usually used for other clinical indications.