Clinical updates on diagnosing glutensensitive enteropathy

In the last twenty years serology for the diagnosis of coeliac disease has improved substantially. As the result of our serological studies in 1998 we proposed a gentle, low-risk, and cost effective algorithm for diagnosing various forms of gluten sensitive enteropathy, using a combination of different antibody determinations, namely IgA Endomysium antibodies (EMA), Tissue-transglutaminase antibodies (IgA anti tTG, IgG anti tTG), IgA-and IgG antigliadin-antibodies. Performing routinely serologic testing contributes to a decreased rate of endoscopic interventions and improves the quality of the patient’s life.