Review: RECENT TREATMENT OF PARKINSONISM WITH RESPECT TO NEUROPROTECTION

This review concisely compiles the limitations of currently available therapies and the most recent research regarding neuroprotective agents, antioxidants, vaccines and various surgical techniques available and being developed for the management of Parkinson's disease (PD). New approaches designed to attenuate the effects of oxidative stress and to provide neuroprotection of striatal dopaminergic neurons in Parkinson's disease include blocking dopamine transporter by mazindol, blocking NMDA receptors by dizocilpine maleate, enhancing the survival of neurons by giving brain-derived neurotrophic factors, providing antioxidants such as vitamin E, or inhibiting monoamine oxidase B.