Effect of acute immobilization on the hematological, red-ox and rheological parameters of erythrocytes in rats

Objectives: Immobilization effects on antioxidant enzymes activities, red-ox variables and rheological parameters of erythrocytes were studied. Background: It is not clear to which extent immobilization-induced oxidative stress may affect erythrocyte rheology. Method: Hematological and red-ox variables, erythrocyte antioxidant enzymes activities, and rheologic parameters of erythrocytes were analyzed. Result: Immobilization stimulated release of stored erythrocytes and reticulocytes, and decrease in rheology parameters of erythrocytes. There were no significant effects of the immobilization on antioxidant enzymes activities and red-ox variables. Conclusion: Immobilization-induced appearance of stored erythrocytes and reticulocytes in circulation is likely to have contributed to the alterations of erythrocyte rheology than red-ox state of blood.