Ceftaroline in complicated skin and skin-structure infections

Paul O Hernandez1, Sergio Lema2, Stephen K Tyring3, Natalia Mendoza2,41University of Texas School of Medicine at San Antonio, San Antonio, TX, 2Woodhull Medical and Mental Health Center, Brooklyn, NY, 3Department of Dermatology, University of Texas Health Science Center at Houston, Houston, TX, USA; 4Department of Dermatology, El Bosque University, Bogotá, ColombiaAbstract: Ceftaroline is an advanced-generation cephalosporin antibiotic recently approved by the US Food and Drug Administration for the treatment of complicated skin and skin-structure infections (cSSSIs). This intravenous broad-spectrum antibiotic exerts potent bactericidal activity by inhibiting bacterial cell wall synthesis. A high affinity for the penicillin-binding protein 2a (PBP2a) of methicillin-resistant Staphylococcus aureus (MRSA) makes the drug especially beneficial to patients with MRSA cSSSIs. Ceftaroline has proved in multiple well-conducted clinical trials to have an excellent safety and efficacy profile. In adjusted doses it is also recommended for patients with renal or hepatic impairment. Furthermore, the clinical effectiveness and high cure rate demonstrated by ceftaroline in cSSSIs, including those caused by MRSA and other multidrug-resistant strains, warrants its consideration as a first-line treatment option for cSSSIs. This article reviews ceftaroline and its pharmacology, efficacy, and safety data to further elucidate its role in the treatment of cSSSIs.Keywords: ceftaroline, cephalosporin, complicated skin and skin-structure infections, cSSSIs, MRSA, Teflaro