The use of non-human animals in biomedical research has given important contributions to the medical progress achieved in our day, but it has also been a cause of heated public, scientific and philosophical discussion for hundreds of years. This review, with a mainly European outlook, addresses the history of animal use in biomedical research, some of its main protagonists and antagonists, and its effect on society from Antiquity to the present day, while providing a historical context with which to understand how we have arrived at the current paradigm regarding the ethical treatment of animals in research.
References
[1]
von Staden, H. Herophilus: The Art of Medicine in Early Alexandria; Cambridge University Press: Cambridge, UK, 1989.
[2]
Court, W.E. Pharmacy from the ancient world to 1100 AD. In Making Medicines: A Brief History of Pharmacy and Pharmaceuticals; Anderson, S., Ed.; Pharmaceutical Press: London, UK, 2005.
[3]
Maehle, A.-H.; Tr？hler, U. Animal experimentation from antiquity to the end of the eighteenth century: Attitudes and arguments. In Vivisection in Historical Perspective; Rupke, N.A., Ed.; Croom Helm: London, UK, 1987.
[4]
Geller, M.J. Phlegm and breath—Babylonian contributions to hippocratic medicine. In Disease in Babylonia; Finkel, I.L., Geller, M.J., Eds.; Brill: Leiden, The Netherlands, 2007.
[5]
Guerrini, A. Experimenting with Humans and Animals: From Galen to Animal Rights; Johns Hopkins University Press: Baltimore, MD, USA, 2003.
[6]
O’Malley, C.D. Andreas Vesalius of Brussels; University of California Press: Berkeley, CA, USA, 1964.
[7]
Regan, T.; Singer, P. Animal Rights and Human Obligations, 2nd ed.; Prentice Hall: Upper Saddle River, NJ, USA, 1989.
[8]
Prioreschi, P. A History of Medicine, Volume 3: Roman Medicine; Horatius Press: Omaha, NE, USA, 1998.
[9]
Prioreschi, P. A History of Medicine, Volume 2: Greek Medicine, 2nd ed.; Horatius Press: Omaha, NE, USA, 1996.
[10]
Prioreschi, P. Experimentation and scientific method in the classical world: Their rise and decline. Med. Hypoth. 1994, 42, 135–148, doi:10.1016/0306-9877(94)90091-4.
[11]
Prioreschi, P. A History of Medicine, Volume 5: Medieval Medicine, 2nd ed.; Edwin Mellen Press: Lewiston, NY, USA, 1996.
[12]
Bacon, F. The second book of francis bacon on the proficience and advancement of learning, divine and human (originally published in 1605). In The Works of Francis Bacon: Baron of Verulam, Viscount St. Albans, and Lord High Chancellor of England; Montague, B., Ed.; Carey and Hart: Philadelphia, PA, USA, 1842.
[13]
Descartes, R. Animals are machines. In Animal Rights and Human Obligations, 2nd; Regan, T., Singer, P., Eds.; Prentice Hall: Upper Saddle River, NJ, USA, 1989; pp. 13–19.
Boden, M.E. Mind as Machine: A History of Cognitive Science; Oxford University Press: Oxford, UK, 2006; Volume 1.
[16]
Allen, C. Animal consciousness. In The Stanford Encyclopedia of Philosophy, Summer 2011; Zalta, E.N., Ed.; Center for the Study of Language and Information, Stanford University: Stanford, CA, USA, 2011.
[17]
Cottingham, J. A brute to the brutes—Descartes’ treatment of animals. In Rene Descartes: Critical Assessments; Moya, G.J.D., Ed.; Routledge: London, UK, 1991.
[18]
Harrison, P. Descartes on animals. Philosoph. Quart. 1992, 42, 219–227.
[19]
Leiber, J. Descartes: The smear and related misconstruals. J. Theory Soc. Behav. 2011, 41, 365–376, doi:10.1111/j.1468-5914.2011.00464.x.
[20]
Dennett, D.C. Animal consciousness: What matters and why. Soc. Res. 1995, 62, 691–710.
[21]
Steiner, G. Descartes on the moral status of animals. Arch. für Geschichte der Philosophie 1998, 80, 268–291.
[22]
Steintrager, J.A. Science and insensibility. In Cruel Delight: Enlightenment Culture and the Inhuman; Steintrager, J.A., Ed.; Indiana University Press: Bloomington, IN, USA, 2004.
[23]
Bayon, H.P. René Descartes, 1596–1650. A short note on his part in the history of medicine. Proc. Roy. Soc. Med. 1950, 43, 783–785.
[24]
Bitbol-Hespériès, A. Cartesian physiology. In Descartes’ Natural Philosophy; Gaukroger, S., Schuster, J., Sutton, J., Eds.; Routledge: London, UK, 2000.
[25]
Steiner, G. Anthropocentrism and its Discontents: The Moral Status of Animals in the History of Western Philosophy; University of Pittsburgh Press: Pittsburgh, PA, USA, 2010.
[26]
Spinoza, B. The Ethics; Echo Library: Teddington, Middlesex, UK, 2006.
[27]
Locke, J. Some Thoughts Concerning Education; Walker: Dublin, Ireland, 1778.
[28]
Kant, I. Lectures on Ethics; Schneewind, J.B., Ed.; Cambridge University Press: Cambridge, UK, 1997.
Linzey, A. The Link between Animal Abuse and Human Violence; Sussex Academic Press: Eastbourne, UK, 2009.
[31]
Gregory, A. Harvey’s Heart: The Discovery of Blood Circulation; Icon Books Ltd.: Cambridge, UK, 2001.
[32]
Wear, A. Early Modern Europe, 1500–1700. In The Western Medical Tradition: 800 BC–1800 AD; Conrad, L.I., Neve, M., Nutton, V., Porter, R., Wear, A., Eds.; Cambridge University Press: Cambridge, UK, 1995.
[33]
Shackelford, J. William Harvey and the Mechanics of the Heart; Oxford University Press: New York, NY, USA, 2003.
[34]
McMullen, E. Anatomy of a physiological discovery: William Harvey and the circulation of the blood. J. Roy. Soc. Med. 1995, 88, 491–498.
[35]
Cohen, I.B. Scientific revolution. In Interactions: Some Contacts between the Natural Sciences and Social Sciences; MIT Press: Cambridge, UK, 1994.
Grene, M.G.; Depew, D.J. Descartes, Harvey, and the emergence of modern mechanism. In The Philosophy of Biology: An Episodic History; Cambridge University Press: Cambridge, UK, 2004; pp. 35–63.
[38]
Weil, E. The Echo of Harvey’s de Motu Cordis (1628) 1628 to 1657. J. History Med. Allied Sci. 1957, XII, 167–174, doi:10.1093/jhmas/XII.4.167.
[39]
Martins e Silva, J. From the discovery of the circulation of the blood to the first steps in hemorheology: Part 2. Revista Portuguesa de Cardiologia 2009, 28, 1405–1439.
[40]
Grene, M.G. Descartes and the heart beat: A conservative innovation. In Wrong for the Right Reasons (Archimedes-New Studies in the History and Phylosophy of Science and Technology); Buchwald, J.Z., Franklin, A., Eds.; Springer: Berlin/Heidelberg, Germany, 2005; Volume 11, pp. 91–97.
[41]
Gorham, G. Mind-body dualism and the Harvey-Descartes controversy. J. History Ideas 1994, 55, 211–234, doi:10.2307/2709897.
[42]
Frank, R.G. Harvey and the Oxford Physiologists: Scientific Ideas and Social Interaction; University of California Press: Berkeley, CA, USA, 1980.
[43]
Wooley, C.F. Palpitation: Brain, heart, and ‘spirits’ in the seventeenth century. J. Roy. Soc. Med. 1998, 91, 157–160.
[44]
Felts, J.H. Richard Lower: Anatomist and physiologist. Ann. Int. Med. 2000, 132, 420–423.
[45]
Wootton, D. Bad Medicine: Doctors Doing Harm Since Hippocrates; Oxford University Press: New York, NY, USA, 2006.
[46]
Dear, P. The meanings of experience. In The Cambridge History of Science, Volume 3: Early Modern Science; Park, K., Daston, L., Eds.; Cambridge University Press: Cambridge, UK, 2006.
[47]
French, R.K. William Harvey’s Natural Philosophy; Cambridge University Press: Cambridge, UK, 1994.
[48]
Van der Worp, H.B.; Howells, D.W.; Sena, E.S.; Porritt, M.J.; Rewell, S.; O’Collins, V.; Macleod, M.R. Can animal models of disease reliably inform human studies? PLoS Med. 2010, 7, doi:10.1371/journal.pmed.1000245.
[49]
Maehle, A.-H. Opium: Explorations of an ambiguous drug-ethical aspects. In Drugs on Trial: Experimental Pharmacology and Therapeutic Innovation in the Eighteenth Century; Editions Rodopi: Amsterdam, The Netherlands, 1999; pp. 193–195.
[50]
Boyle, R. New Experiments Physico-Mechanicall, Touching the Spring of the Air, and its Effects (Made in a New Pneumatical Engine): Written by Way of Letter to the Right Honorable Charles, Lord Vicount of Dungarvan, Eldest Son to the Earl of Corke/by the Honorable Robert Boyle, Esq.; Printed by H. Hall: Oxford, UK, 1660.
[51]
West, J.B. Robert Boyle’s landmark book of 1660 with the first experiments on rarified air. J. Appl. Physiol. 2005, 98, 31–39, doi:10.1152/japplphysiol.00759.2004.
[52]
West, J.B. Stephen Hales: Neglected respiratory physiologist. J. Appl. Physiol. 1984, 57, 635–639.
[53]
Smith, I.B. The impact of Stephen Hales on medicine. J. Roy. Soc. Med. 1993, 86, 349–352.
[54]
Clark-Kennedy, A.E. Stephen Hales, DD, FRS. Br. Med. J. 1977, 2, 1656–1658, doi:10.1136/bmj.2.6103.1656.
[55]
Porter, R. The eighteenth century. In The Western Medical Tradition: 800 BC-1800 AD; Conrad, L.I., Neve, M., Nutton, V., Porter, R., Wear, A., Eds.; Cambridge University Press: Cambridge, UK, 1995.
[56]
Frixione, E. Albrecht Von Haller (1708–1777). J. Neurol. 2006, 253, 265–266, doi:10.1007/s00415-006-0998-x.
[57]
Duffin, J. Interrogating life: History of physiology. In History of Medicine: A Scandalously Short Introduction, 2nd ed.; University of Toronto Press: Toronto, Canada, 2010; p. 40.
[58]
Buess, H. William Harvey and the foundation of modern haemodynamics by Albrecht Von Haller. Med. Hist. 1970, 14, 175–182, doi:10.1017/S0025727300015362.
[59]
Fye, W.B. Albrecht von Haller. Clin. Cardiol. 1995, 18, 291–292, doi:10.1002/clc.4960180513.
[60]
Bay, J.C. Albrecht Von Haller medical encyclopedist. Bull. Med. Library Assoc. 1960, 48, 393–403.
[61]
Festing, S. Animal experiments: The long debate. New Sci. 1989, 121, 51–54.
[62]
Maehle, A.H. Literary responses to animal experimentation in seventeenth- and eighteenth-century britain. Med. Hist. 1990, 34, 27–51, doi:10.1017/S0025727300050250.
[63]
Maehle, A.-H. Drugs on Trial: Experimental Pharmacology and Therapeutic Innovation in the Eighteenth Century; Editions Rodopi: Amsterdam, The Netherlands, 1999.
[64]
Cajavilca, C.; Varon, J.; Sternbach, G.L. Luigi Galvani and the foundations of electrophysiology. Resuscitation 2009, 80, 159–162, doi:10.1016/j.resuscitation.2008.09.020.
[65]
Piccolino, M. Luigi Galvani and animal electricity: Two centuries after the foundation of electrophysiology. Trends Neurosci. 1997, 20, 443–448, doi:10.1016/S0166-2236(97)01101-6.
[66]
Roe, S.A. Matter, Life, and Generation: Eighteenth-Century Embryology and the Haller-Wolff Debate; Cambridge University Press: Cambridge, UK, 1981.
[67]
Nuffield Council on Bioethics. The context of animal research: Past and present. In The Ethics of Research Involving Animals; Nuffield Council on Bioethics: London, UK, 2005.
Schopenhauer, A. On the Basis of Morality; Swan Sonnenschein & Co., Ltd.: London, UK, 1903.
[70]
Rousseau, J.-J. Discourse on the Origin of Inequality; Filiquarian Publishing, LLC: Minneapolis, MN, USA, 2007.
[71]
Bentham, J. An Introduction to the Principles of Morals and Legislation; W. Pickering: London, UK, 1823.
[72]
Bentham, J. Anarchical fallacies: Being an examination of the declarations of rights issued during the french revolution. In The Works of Jeremy Bentham; Bowring, J., Ed.; William Tate: London, UK, 1843.
[73]
Boralevi, L.C. Bentham and the Oppressed; W. de Gruyter: Berlin, Germany, 1984.
[74]
Jacyna, L.S. The localization of disease. In Medicine Transformed: Health, Disease and Society in Europe, 1800–1930; Brunton, D., Ed.; Manchester University Press: Manchester, UK, 2004.
[75]
Thomas, L. Biomedical science and human health. Yale J. Biol. Med. 1978, 51, 133–142.
[76]
Duffin, J. First do no harm: History of treatment, pharmacology and pharmaceuticals. In History of Medicine: A Scandalously Short Introduction, 2nd ed.; University of Toronto Press: Toronto, Canada, 2010; p. 98.
[77]
Bynum, W.F. Conclusion: Did science matter? In Science and the Practice of Medicine in the Nineteenth Century; Cambridge University Press: Cambridge, UK, 1994; pp. 218–226.
[78]
Lesch, J.E. The Paris Academy of Medicine and Experimental Science. In The Investigative Enterprise: Experimental Physiology in Nineteenth-Century Medicine; Coleman, W., Holmes, F.L., Eds.; University of California Press: Berkeley, CA, USA, 1988.
[79]
Elliot, P. Vivisection and the emergence of experimental physiology in nineteenth-century France. In Vivisection in Historical Perspective; Rupke, N.A., Ed.; Croom Helm: London, UK, 1987; p. 125.
[80]
LaFollette, H.; Shanks, N. Animal experimentation: The legacy of Claude Bernard. Int. Stud. Philos. Sci. 1994, 8, 195–210.
[81]
Orlans, B. History and ethical regulation of animal experimentation: An international perspective. In A Companion to Bioethics; Kuhse, H., Singer, P., Eds.; Blackwell Publishing: Oxford, UK, 1998.
[82]
Tubbs, R.S.; Loukas, M.; Shoja, M.M.; Shokouhi, G.; Oakes, W.J. Fran？ois Magendie (1783–1855) and his contributions to the foundations of neuroscience and neurosurgery. J. Neurosurg. 2008, 108, 1038–1042.
[83]
Schiller, J. Physiology’s struggle for independence in the first half of the nineteenth century. Hist. Sci. 1968, 7, 64–89.
[84]
Monamy, V. Animal Experimentation: A Guide to the Issues; Cambridge University Press: Cambridge, UK, 2000.
[85]
Ryder, R.D. Victorian consolidation. In Animal Revolution: Changing Attitudes Toward Speciesism; Berg: Oxford, UK, 2000; pp. 95–120.
[86]
Bloch, H. Francois Magendie, Claude Bernard, and the interrelation of science, history, and philosophy. South. Med. J. 1989, 82, 1259–1261, doi:10.1097/00007611-198910000-00013.
[87]
Normandin, S. Claude Bernard and an introduction to the study of experimental medicine: “Physical vitalism”, dialectic, and epistemology. J. Hist. Med. Allied Sci. 2007, 62, 495–528, doi:10.1093/jhmas/jrm015.
[88]
Rudacille, D. Viruses, vaccines and vivisection. In The Scalpel and the Butterfly: The Conflict between Animal Research and Animal Protection; University of California Press: Berkeley, CA, USA, 2001; pp. 17–29.
[89]
Bernard, C. An Introduction to the Study of Experimental Medicine; Macmillan: New York, NY, USA, 1927.
[90]
Berkowitz, C. Disputed discovery: Vivisection and experiment in the 19th century. Endeavour 2006, 30, 98–102.
[91]
Bynum, W.F. Medicine in the laboratory. In Science and the Practice of Medicine in the Nineteenth Century; Press Syndicate of the University of Cambridge: Cambridge, UK, 1994.
[92]
Zimmer, H.G. Carl Ludwig: The man, his time, his influence. Pflügers Archiv-Eur. J. Physiol. 1996, 432, R9–R22.
[93]
Lenoir, T. Science for the clinic: Science policy and the formation of Carl Ludwig’s institute in leipzig. In The Investigative Enterprise: Experimental Physiology in Nineteenth-Century Medicine; Coleman, W., Holmes, F.L., Eds.; University of California Press: Berkeley, CA, USA, 1988.
[94]
Cahan, D. Hermann von Helmholtz and the Foundations of Nineteenth-Century Science; University of California Press: Berkeley, CA, USA, 1993.
[95]
Otis, L. Johannes Peter Müller (1801–1858). The Virtual Laboratory; Max Planck Institute for the History of Science: Berlin, Germany, 2004. Available online: http://vlp.mpiwg-berlin.mpg.de/essays/data/enc22 (accessed on 13 March 2013).
[96]
Coleman, W.; Holmes, F.L. The Investigative Enterprise: Experimental Physiology in Nineteenth-Century Medicine; University of California Press: Berkeley, CA, USA, 1988.
[97]
O’Malley, C.D. The History of Medical Education; University of California Press: Los Angeles, CA, USA, 1970.
[98]
Manuel, D. Marshall Hall (1790–1857): Vivisection and the development of experimental physiology. In Vivisection in Historical Perspective; Rupke, N.A., Ed.; Croom Helm: London, UK, 1987; p. 78.
[99]
Preece, R. The history of animal ethics in western culture. In The Psychology of the Human-Animal Bond: A Resource for Clinicians and Researchers; Blazina, C., Boyra, G., Shen-Miller, D., Eds.; Springer: New York, NY, USA, 2011; pp. 45–62.
[100]
Guerrini, A. Animal experiments and antivivisection debates in the 1820s. In Frankenstein’s Science: Experimentation and Discovery in Romantic Culture, 1780–1830; King, C.K., Goodall, J.R., Eds.; Ashgate: Burlington, Canada, 2008.
[101]
Olmsted, J.M.D. Fran？ois Magendie; Arno Press: New York, NY, USA, 1944.
[102]
Gross, C.G. Claude Bernard and the constancy of the internal environment. The Neuroscientist 1998, 4, 380–385, doi:10.1177/107385849800400520.
[103]
Broennle, A.M. Lectures on anesthetics and on asphyxia (book review). Anesth. Analg. 1991, 72, 132, doi:10.1213/00000539-199101000-00030.
[104]
Lee, J.A. Claude Bernard (1813–1878). Anaesthesia 1978, 33, 741–747, doi:10.1111/j.1365-2044.1978.tb08473.x.
[105]
Davis, N.K. The moral aspects of vivisection. North Am. Rev. 1885, 140, 203–220.
[106]
Inoue, T.; Kodama, Y. Future Alternatives in “3Rs”: Learning from History. In Proceedings of the 6th World Congress on Alternatives & Animal Use in the Life Sciences, Tokyo, Japan, 21–25 August 2007; pp. 257–260.
[107]
Debré, P. Louis Pasteur; Johns Hopkins University Press: Baltimore, MD, USA, 2000.
[108]
Rey, R. The History of Pain; Harvard University Press: Cambridge, MA, USA, 1998.
[109]
Snow, S.J. Blessed Days of Anaesthesia: How Anaesthetics Changed the World; Oxford University Press: New York, NY, USA, 2008.
[110]
Richards, S. Anaesthetics, ethics and aesthetics: Vivisection in the late nineteenth-century british laboratory. In The Laboratory Revolution in Medicine; Cunningham, A., Williams, P., Eds.; Cambridge University Press: Cambridge, UK, 1992; pp. 142–169.
[111]
Feller, D.A. Dog fight: Darwin as animal advocate in the antivivisection controversy of 1875. Stud. Hist. Philos. Sci. Part C: Stud. Hist. Philos. Biol. Biomed. Sci. 2009, 40, 265–271, doi:10.1016/j.shpsc.2009.09.004.
[112]
Tait, L. The Uselessness of Vivisection upon Animals as a Method of Scientific Research; The Herald Press: Birmingham, West Midlands, UK, 1882; Volume II.
[113]
Elliot, C.W.; Walker, F.A.; Paddock, F.K. Vivisection—A statement in behalf of science. Science 1896, 3, 421–426.
[114]
Johnson, E.M. Charles Darwin and the vivisection outrage. The Primate Diaries. Scientific American, 2011. Available online: http://blogs.scientificamerican.com/primate-diaries/2011/10/06/vivisection-outrage/ (accessed on 13 March 2013).
[115]
Darwin, C. Darwin on vivisection—Experiments on living animals necessary to the progress of physiological study. The New York Times 1881.
[116]
Gaw, J.L. “A Time to Heal”: The Diffusion of Listerism in Victorian Britain; American Philosophical Society: Philadelphia, PA, USA, 1999.
[117]
Richards, S. Drawing the life-blood of physiology: Vivisection and the physiologists’ dilemma, 1870–1900. Ann. Sci. 1986, 43, 27–56, doi:10.1080/00033798600200111.
[118]
Dolan, K. The coming of the law on laboratory animals. In Laboratory Animal Law: Legal Control of the Use of Animals in Research, 2nd ed.; Blackwell Publisher: Oxford, UK, 2007.
[119]
Connor, J.T. Cruel knives? Vivisection and biomedical research in Victorian English Canada. Can. Bull. Med. Hist. 1997, 14, 37–64.
[120]
Semmelweis, I. Etiology, Concept and Prophylaxis of Childbed Fever; University of Wisconsin Press: Madison, WI, USA, 1983.
[121]
Flack, H.D. Louis Pasteur’s discovery of molecular chirality and spontaneous resolution in 1848, together with a complete review of his crystallographic and chemical work. Acta Crystallogr. Sec. A 2009, 65, 371–389, doi:10.1107/S0108767309024088.
[122]
Bazin, H. The swine erypselas vaccine: 1883. In Vaccination—A History: From Lady Montagu to Genetic Engineering; John Libbey Eurotext Ltd.: Montrouge, France, 2011.
[123]
Hansen, B. America’s first medical breakthrough: How popular excitement about a french rabies cure in 1885 raised new expectations for medical progress. Am. Hist. Rev. 1998, 103, 373–418, doi:10.2307/2649773.
[124]
Schwartz, M. The life and works of Louis Pasteur. J. Appl. Microbiol. 2001, 91, 597–601, doi:10.1046/j.1365-2672.2001.01495.x.
[125]
Morton, D.B. Humane endpoints in animal experimentation for biomedical research. In Humane Endpoints in Animals Experiments for Biomedical Research; Hendriksen, C.F.M., Morton, D.B., Eds.; Royal Society of Medicine Press: London, UK, 1999; pp. 5–12.
[126]
Rosenau, M.J. The pasteur prophylactic treatment. In Preventive Medicine and Hygiene, 2nd ed.; D. Appleton and Co.: New York, NY, USA, 1916; pp. 45–53.
[127]
Vallery-Radot, R. The Life of Pasteur; Doubleday: Garden City, NY, USA, 1911.
[128]
Vallery-Radot, R. Louis Pasteur—His Life and Labours; D. Appleton and Company: New York, NY, USA, 1886.
[129]
Howard-Jones, N. Robert Koch and the cholera vibrio: A centenary. Br. Med. J. 1984, 288, 379–381, doi:10.1136/bmj.288.6414.379.
[130]
Ullmann, A. Pasteur–Koch: Distinctive ways of thinking about infectious diseases. Microbe 2007, 2, 383–387.
[131]
Brock, T.D. Robert Koch: A Life in Medicine and Bacteriology; ASM Press: Washington, DC, USA, 1988.
[132]
Bosch, F.; Rosich, L. The contributions of Paul Ehrlich to pharmacology: A tribute on the occasion of the centenary of his Nobel Prize. Pharmacology 2008, 82, 171–179, doi:10.1159/000149583.
[133]
Silverstein, A.M. The standardization of toxins and antitoxins. In Paul Ehrlich’s Receptor Immunology: The Magnificent Obsession; Elsevier Science: Amsterdam, The Netherlands, 2001; pp. 41–54.
[134]
Kantha, S.S. A centennial review: The 1890 tetanus antitoxin paper of von Behring and Kitasato and the related developments. Keio J. Med. 1991, 40, 35–39, doi:10.2302/kjm.40.35.
[135]
Linton, D.S. From immunization to serum therapy. In Emil von Behring: Infectious Disease, Immunology, Serum Therapy; American Philosophical Society: Philadelphia, PA, USA, 2005.
[136]
Pearce, R.M. Research in medicine. II. The development of laboratories for the medical sciences. Popul. Sci. Month. 1912, 80, 548–562.
[137]
Davis, N. History of medical progress during the last half of the nineteenth century completed. The present status of medical investigations and progress, and the indications of further advancement. In History of Medicine; Cleveland Press: Chicago, IL, USA, 1903.
[138]
Ernst, H.C. Animal Experimentation; A Series of Statements Indicating its Value to Biological and Medical Science; Little, Brown, and Company: Boston, MA, USA, 1902.
[139]
Romano, T.M. Part III. The medical sciences: Critics and allies. In Making Medicine Scientific: John Burdon Sanderson and the Culture of Victorian Science; Johns Hopkins University Press: Baltimore, MD, USA, 2002.
[140]
Warner, J.H. Ideals of science and their discontents in late nineteenth-century American medicine. Isis 1991, 82, 454–478.
[141]
Warner, J.H. The fall and rise of professional mystery. In The Laboratory Revolution in Medicine; Cunningham, A., Williams, P., Eds.; Cambridge University Press: Cambridge, UK, 1992; pp. 110–141.
[142]
Medical Advances and Animal Research—The Contribution of Animal Science to the Medical Revolution: Some Case Histories; Understanding Animal Research: London, UK, 2007.
[143]
Foundation for Biomedical Research. Available online: http://www.fbresearch.org/nobelprize/ (accessed on 12 March 2013).
[144]
Kirkwood, T.B.L. A systematic look at an old problem. Nature 2008, 451, 644–647, doi:10.1038/451644a.
[145]
Kinsella, K.; He, W. An Aging World: 2008; U.S. Census Bureau, International Population Reports, P95/09-1; U.S. Government Printing Office: Washington, DC, USA, 2009.
[146]
Oeppen, J.; Vaupel, J.W. Broken limits to life expectancy. Science 2002, 296, 1029–1031, doi:10.1126/science.1069675.
[147]
Rudacille, D. The dogs of war. In The Scalpel and the Butterfly: The Conflict between Animal Research and Animal Protection; University of California Press: Berkeley, CA, USA, 2001; pp. 55–79.
[148]
Preece, R. Animal sensibilities in the Shavian era. In Animal Sensibility and Inclusive Justice in the Age of Bernard Shaw; University of British Columbia Press: Vancouver, Canada, 2011; pp. 93–143.
[149]
Liddick, D. History and philosophy of the animal rights movement. In Eco-Terrorism: Radical Environmental and Animal Liberation Movements; Praeger: Westport, CT, USA, 2006.
[150]
Lederer, S.E. Political animals. The shaping of biomedical research literature in twentieth-century america. Isis 1992, 83, 61–79.
[151]
Baumans, V. The welfare of laboratory mice. In The Welfare of Laboratory Animals; Kaliste, E., Ed.; Springer: Dordrecht, The Netherlands, 2007; Volume 2, pp. 119–152.
[152]
Kaliste, E.; Mering, S. The welfare of laboratory rats. In The Welfare of Laboratory Animals; Kaliste, E., Ed.; Springer: Dordrecht, The Netherlands, 2007; Volume 2, pp. 153–180.
[153]
Lindsey, J.R.; Baker, H.J. Historical foundations. In The Laboratory Rat; Suckow, M.A., Weisbroth, S.H., Franklin, C.L., Eds.; Elsevier: Amsterdam, The Netherlands, 2006.
[154]
Hedrich, H.J. The history and development of the rat as a laboratory animal model. In The Laboratory Rat; Krinke, G., Ed.; Academic: Waltham, MA, USA, 2000; pp. 3–16.
[155]
Henig, R.M. The Monk in the Garden: The Lost and Found Genius of Gregor Mendel, the Father of Genetics; Houghton Mifflin: Boston, MA, USA, 2001.
[156]
Gordon, J.W.; Ruddle, F.H. Integration and stable germ line transmission of genes injected into mouse pronuclei. Science 1981, 214, 1244–1246.
[157]
Morse, H.C. Building a better mouse: One hundred years of genetics and biology. In The Mouse in Biomedical Research: History, Wild Mice, and Genetics; Fox, J.G., Ed.; Academic Press: Waltham, MA, USA, 2007.
[158]
Davisson, M.T.; Linder, C.C. History of mouse genetics and research with the laboratory mouse. In The Laboratory Mouse; Hedrich, H.J., Bullock, G.R., Eds.; Elsevier Academic Press: Oxford, UK, 2004; pp. 16–20.
[159]
Sixth Report on the Statistics on the Number of Animals Used for Experimental and Other Scientific Purposes in the Member States of the European Union; European Commission: Brussels, Belgium, 2010.
[160]
Singer, P. Animal liberation at 30. The New York Review of Books 2003.
[161]
Ryder, R.D. Speciesism. In Animal Revolution: Changing Attitudes toward Speciesism; Berg: Oxford, UK, 2000; pp. 223–250.
[162]
Singer, P. Animal Liberation; HarperCollins Publishers: New York, NY, USA, 2001.
[163]
Singer, P. About ethics. In Practical Ethics; Cambridge University Press: Cambridge, UK, 2011; pp. 1–15.
[164]
Singer, P. Equality for animals? In Practical Ethics; Cambridge University Press: Cambridge, UK, 2011; pp. 48–70.
[165]
Singer, P. Setting limits on animal testing. The Sunday Times 2006.
[166]
Regan, T. The case for animal rights. In Animal Rights and Human Obligations, 2nd; Regan, T., Singer, P., Eds.; Prentice Hall: Upper Saddle River, NJ, USA, 1989.
[167]
Orlans, F.B. In the Name of Science: Issues in Responsible Animal Experimentation; Oxford University Press: Cary, NC, USA, 1996.
[168]
Cohen, C.; Regan, T. The Animal Rights Debate; Rowman & Littlefield Publishers: Lanham, MD, USA, 2001.
[169]
Conn, P.M.; Parker, J.V. The Animal Research War; Palgrave Macmillan: New York, NY, USA, 2008.
[170]
Liddick, D. Eco-Terrorism: Radical Environmental and Animal Liberation Movements; Praeger: Westport, CT, USA, 2006.
[171]
Regan, T.; Masson, J.M. Empty Cages: Facing the Challenge of Animal Rights; Rowman & Littlefield Publishers: Lanham, MD, USA, 2005.
[172]
Goodwin, F.K.; Morrison, A.R. Scientists in bunkers: How appeasement of “animal rights” activism has failed. In Cerebrum: The Dana Forum on Brain Science; Donway, W., Ed.; Diane Publishing Company: Darby, PA, USA, 1999; Volume 1, pp. 50–62.
[173]
Birke, L.; Michael, M. Views from behind the barricade. New Sci. 1992, 134, 29–32.
[174]
Cressey, D. Battle scars. Nature 2011, 470, 452–453, doi:10.1038/470452a.
[175]
Rollin, B.E. The ethics of animal research. Talking point on the use of animals in scientific research. EMBO Rep. 2007, 8, 521–525, doi:10.1038/sj.embor.7400996.
[176]
Aldhous, P.; Coghlan, A.; Copley, J. Animal experiments: Let the people speak. New Sci. 1999, 162, 26–31.
[177]
Crettaz von Roten, F. Public perceptions of animal experimentation across Europe. Public Underst. Sci. 2012, doi:10.1177/0963662511428045.
[178]
Singer, P. Ethics into Action: Henry Spira and the Animal Rights Movement; Rowman & Littlefield Publishers: Lanham, MD, USA, 2000.
[179]
Russell, W.M. The three Rs: Past, present and future. Anim. Welf. 2005, 14, 279–286.
[180]
Balls, M. Professor W.M.S. Russell (1925–2006): Doyen of the three Rs. In Proceedings of the 6th World Congress on Alternatives & Animal Use in the Life Sciences, Tokyo, Japan, 21–25 August 2007; pp. 1–7.
[181]
Stephens, M.L.; Goldberg, A.M.; Rowan, A.N. The first forty years of the alternatives approach: Refining, reducing, and replacing the use of laboratory animals. In The STate of the Animals: 2001; Salem, D.J., Rowan, A.N., Eds.; Humane Society Press: Washington, DC, USA, 2001; pp. 121–135.
[182]
Russell, W.M.S.; Burch, R.L. The Principles of Humane Experimental Technique; Methuen & Co. Ltd.: London, UK, 1959.
[183]
Balls, M. Alternatives to animal experiments: Serving in the middle ground. AATEX 2005, 11, 4–14.
[184]
Smyth, D.H. Alternatives to Animal Experiments; Scolar Press [for] the Research Defence Society: London, UK, 1978.
[185]
Olsson, I.A.S.; Robinson, P.; Sand？e, P. Ethics of animal research. In Handbook of Laboratory Animal Science-Volume I: Essential Principles and Practices, 3rd; Hau, J., Schapiro, S.J., Eds.; CRC Press: Boca Raton, FL, USA, 2011.
[186]
Frey, R.G. Utilitarianism and animals. In The Oxford Handbook of Animal Ethics; Beauchamp, T.L., Frey, R.G., Eds.; Oxford University Press: New York, NY, USA, 2011; pp. 172–197.
[187]
Sztybel, D. Animal rights law: Fundamentalism versus pragmatism. J. Crit. Anim. Stud. 2007, 5, 1–37.
[188]
Rollin, B.E. Reasonable partiality and animal ethics. Ethical Theory Moral Pract. 2005, 8, 105–121, doi:10.1007/s10677-005-3297-1.
[189]
Francione, G.L. Rain without Thunder: The Ideology of the Animal Rights Movement; Temple University Press: Philadelphia, PA, USA, 1996.
[190]
Francione, G.L. Animal rights theory and utilitarianism: Relative normative guidance. Between the Species, 2003. Available online: http://digitalcommons.calpoly.edu/cgi/viewcontent.cgi?article=1054&context=bts (accessed on 13 March 2013).
[191]
Burch, R.L. The progress of humane experimental technique since 1959: A personal view. Altern. Lab. Anim. 1995, 23, 776–783.
[192]
Stephens, M.L. Pursuing Medawar’s challenge for full replacement. ALTEX Proc. 2012, 1, 23–26.
[193]
Mukerjee, M. Trends in animal research. Sci. Am. 1997, 276, 86–93, doi:10.1038/scientificamerican0297-86.
[194]
Carlsson, H.-E.; Hagelin, J.; Hau, J. Implementation of the ‘three Rs’ in biomedical research. Vet. Record 2004, 154, 467–470, doi:10.1136/vr.154.15.467.
[195]
Kulpa-Eddy, J.; Snyder, M.; Stokes, W. A review of trends in animal use in the united states (1972–2006). In Proceedings of the 6th World Congress on Alternatives & Animal Use in the Life Sciences, Tokyo, Japan, 21–25 August 2007; Volume 14, pp. 163–165.
[196]
Rowan, A.N. A brief history of the animal research debate and the place of alternatives. AATEX 2007, 12, 203–211.
[197]
Taylor, K.; Gordon, N.; Langley, G.; Higgins, W. Estimates for worldwide laboratory animal use in 2005. ATLA 2008, 36, 327–342.
[198]
Ormandy, E.H.; Schuppli, C.A.; Weary, D.M. Worldwide trends in the use of animals in research: The contribution of genetically-modified animal models. Altern. Lab. Anim. 2009, 37, 63–68.
[199]
Festing, S.; Wilkinson, R. The ethics of animal research—Talking point on the use of animals in scientific research. EMBO Rep. 2007, 8, 526–530, doi:10.1038/sj.embor.7400993.
[200]
Executive Committee of the Congress. Background to the three Rs declaration of bologna, as adopted by the 3rd world congress on alternatives and animal use in the life sciences, bologna, italy, on 31 august 1999. Altern. Lab. Anim. 2009, 37, 286–289.
[201]
Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the Protection of Animals Used for Scientific Purposes; European Commission: Brussels, Belgium, 2010.
[202]
Basel Declaration Society. Position paper: 3R in research—how can the concept of 3Rs best be implemented in the context of fundamental research? Adopted on 17 October 2011. Available online: http://www.basel-declaration.org/basel-declaration/the-3rs/ (accessed on 13 March 2013).
[203]
Basel Declaration Society. Basel declaration: A call for more trust, transparency and communication on animal research. Adopted on 29 November 2010. Available online: http://www.basel-declaration.org/basel-declaration/ (accessed on 13 March 2013).
[204]
Louhimies, S. Eu Directive 2010/63/EU: “Implementing the three Rs through policy”. ALTEX Proc. 2012, 1, 27–33.
