Amyloid precursor protein regulates brain cholesterol metabolism

There is a scientific evidence, suggesting that amyloid precursor protein (APP) processing and Alzheimer's (AD) amyloid beta generation are regulated by cholesterol. Latest study by Liu et al. published in Neuron (56:66-78, 2007) shines a new light on the connection between cholesterol metabolism and APP processing. At this time the story is reversed - now it appears that APP proteolytic fragments are regulating cholesterol levels in brain and inside the cells.