Release Kinetic Determination of Once a Day Prolong Release Tablets of Pramipexole Dihydrochloride Using Model-Dependent Approaches

The aim of presented research work was to determine release kinetic pattern of Pramipexole dihydrochloride prolong release tablets using model dependent approaches. Various release kinetic models like Zero order, First order, Higuchi, Korsmeymer-Peppas, Hixson–Crowell and Weibull were applied to developed prolonged release tablet of Pramipexole dihydrochloride. The criteria for selecting the most appropriate model was lowest sum of square of residuals. Residual values between predicted and observed data were used to calculate the sum of squares of residuals. Lowest sum of square of residuals indicate the minimum variance between the predicted and observed dissolution data. The entire release profile was compared by taking the absolute difference (residual) between the predicted and observed calculated AUC data.