BIOLOGICAL ACTIVITIES OF PURINE ANALOGUES: A REVIEW

The purine analogues are a new class of nonclassical antimicrobial agents that bind with riboswitches. Purine (adenine) analogues are having antimicrobial, antifungal, antitumour, antiproliferative, antiviral and activity against HSV-1. Riboswitches are structured RNA domains that can bind directly to speci c ligands and regulate gene expression. These RNA elements are located most commonly within the non-coding regions of bacterial mRNAs, because these genes were involved in fundamental metabolic pathways in certain bacterial pathogens. Purine-binding riboswitches may be targets for the development of novel antimicrobial agents. In vitro the designed compounds can be bound by purine riboswitches aptamer with affinities comparable to that of the natural ligand and many of these compounds also inhibit microbial growth.