Synthesis and Pharmacological Evaluation of Certain Schiff Bases and Thiazoldine Derivatives as AT1 Angiotension-II(AII) Receptor Antagonists

Many Schiff bases were prepared by condensation reaction of nitro compound containing biphenyl ether amines with aromatic aldehydes and ketone derivatives and thiazolidines wer prepared by Schiff base with thioglycolic acid. The synthesized compounds were screened for AT1 Angiotension (A II) Receptor Antagonist activity. The nitro compound containing biphenyl ether Schiff bases and thiazolidines shows good activity compared with losartan.