Although atypical antipsychotic drugs (APDs) have led to significant advances in the treatment of psychotic disorders, they still induce metabolic disturbances. We aimed at characterizing the metabolic consequences of a risperidone treatment and at establishing a link with noninvasive MR markers, in order to develop a tool for predicting symptoms of the metabolic syndrome. Fat deposition and liver morphometry were assessed by T1-weighted imaging. Fatty acid composition and fat accumulations in tissues were determined using MR spectroscopy with and without water suppression, respectively. Risperidone treatment induced a weight gain accompanied with metabolic disturbances such as hyperglycemic status, an increase in visceral adipose tissue (VAT), and liver fat depositions. Correlations using Methylene-Water Ratio (MWR) and Polyunsaturated Index (PUI) demonstrated a concomitant increase in the weight gain, VAT and liver fat depositions, and a decrease in the quantity of polyunsaturated fatty acids. These results were consistent with a hepatic steatosis state. We evaluated the ability of MR techniques to detect subtle metabolic disorders induced by APDs. Thus, our model and methodology offer the possibility to investigate APDs side effects in order to improve the health conditions of schizophrenic patients. 1. Introduction Antipsychotic drugs (APDs) are widely used in current psychiatric practice and are commonly classified as typical (conventional) or atypical (second generation). Atypical APDs have been introduced in clinical practice after 1990, including clozapine, olanzapine, quetiapine, and risperidone. Atypical APDs cause less extrapyramidal symptoms (tremors) than typical APDs. However, both of them produce a weight gain [1–3], which increases the risk to develop a metabolic syndrome [4] associating several disorders such as diabetes mellitus, hypertension, hyperglycemia, dyslipidemia, and abdominal fat deposition [4, 5]. The excess of visceral adipose tissue (VAT) mass is particularly correlated to the prevalence of metabolic syndrome and insulin resistance [6]. Indeed, abnormal VAT depositions lead to the storage of lipids in undesired organs such as pancreas, skeletal muscle, heart, and liver. This so-called “ectopic fat deposition” contributes to the development of metabolic syndrome [6–12]. VAT accumulation could thus represent a biomarker of metabolic disturbances, as used in clinic through the measurement of waist circumference in replacement of the body mass index [5]. Nevertheless, the susceptibility to develop a metabolic syndrome is not
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