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慢性肾脏病肾组织炎症信号通路p38MAPK的调节机制及中药的干预作用

Keywords: 慢性肾脏病,中药,p38丝裂原活化蛋白激酶,信号通路

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Abstract:

肾组织的炎症反应及其相关的组织损伤(如肾小球硬化和肾间质纤维化)是导致慢性肾脏病(chronickidneydisease,CKD)进展至终末期肾病的重要因素。其中,p38丝裂原活化蛋白激酶(mitogen-activatedproteinkinase,MAPK)信号通路能够调控多种核转录因子的表达和生物活性,还可以影响下游炎症介质的合成,并参与炎症细胞的活化,在肾脏疾病炎症损伤中发挥着重要的作用。某些单味中药及其提取物(如大黄素、黄连素)以及一些中药复方(如益肾活血汤)可以通过调节p38MAPK信号通路而影响肾组织内炎症反应,从而,减轻肾小球、肾间质炎症损伤。

References

[1]  Barsoum R S. Chronic kidney disease in the developing world[J]. N Engl J Med,2006,354:997.
[2]  Vidt D G. Inflammation in renal disease[J]. Am J Cardiol,2006,97:20A.
[3]  Stenvinkel P. The role of inflammation in the anaemia of end-stage renal disease[J]. Nephrol Dial Transplant,2001,7:36.
[4]  Papayianni A. Cytokines,growth factors and other inflammatory mediators in glomerulonephritis[J]. Ren Fail,1996,18:725.
[5]  Han J,Jing Y,Li Z,et al. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation[J]. Nature,1997,386:296.
[6]  Sanz A B,Sanchez-Nino M D,Ramos A M,et al. NF-kappaB in renal inflammation[J]. J Am Soc Nephrol,2010,21:1254.
[7]  Cuadrado A,Nebreda A R. Mechanisms and functions of p38 MAPK signalling[J]. Biochem J,2010,429:403.
[8]  Cuenda A,Rousseau S. p38 MAP-Kinases pathway regulation,function and role in human diseases[J]. Biochim Biophys Acta,2007,1773:1358.
[9]  Ono K,Han J H. The p38 signal transduction pathway activation and function[J]. Cell Signal,2000,12:1.
[10]  Tian W,Zhang Z,Cohen D M. MAPK signalling and the kidney[J]. Am J Physiol Renal Physiol,2000,279:593.
[11]  Enslen H,Raingeaud J,Davis R J. Selective activation of p38 mitogen activated protein(MAP)kinase isoforms by the MAP kinase kinases MKK3 and MKK6[J]. J Biol Chem,1998,273:1741.
[12]  Chin B Y,Mohsenin A,Li S X,et al. Stimulation of pro-α1(I)colagen by TGF-β1 in mesangial cells:role of the p38MAPK pathway[J]. Am J Physiol Renal Physiol,2001,280:F495.
[13]  Gruden G,Zonca S,Hayward A,et al. Mechanical stretch-induced fibronectin and transforming growth factor-β1 production in human mesangial cells is p38 mitogen-activated protein kinase dependent[J]. Diabetes,2000,49:655.
[14]  Stambe C,Nikolic-Paterson D J,Hill P A,et al. p38 mitogen-activated protein kinase activation and cell localization in human glomerulonephritis:correlation with renal injury[J]. J Am Soc Nephrol,2004,15:326.
[15]  娄宁,余学清,祝胜郎,等.血管紧张素Ⅱ激活巨噬细胞株p38MAPK信号通路并诱导其增殖[J].中国免疫学杂志,2005,21(6):416.
[16]  赵毅,李铁成,金安,等. p38 MAPK对冲击波促进T淋巴细胞增殖和分泌IL-2的作用[J].吉林大学学报:医学版,2007,33(5):815.
[17]  张军峰,姚翠微,刘华锋,等. p38MAPK在 IL-18诱导肾小管上皮细胞转分化中的作用[J].中国应用生理学杂志,2010,26(2):199.
[18]  魏倩萍,邓华聪,赵劼. p38MAPK对大鼠肾小球系膜细胞表达NF-κB和COX-2的调控[J].第二军医大学学报,2008,29(3):241.
[19]  Isaka Y,Fujiwara Y,Ueda N,et al. Glomerulosclerosis induced by in vivo transfection of transforming growth factor-beta or platelet-derived growth factor gene into the rat kidney[J]. J Clin Invest,1993,92:2597.
[20]  Border W A,Noble N A,Yamamoto T,et al. Nayural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease[J]. Nature,1992,360:361.
[21]  Wan Y,Gu L,Suzuki K,et al. Multi-glycoside of Tripterygium wilfordii Hook f. ameliorates proteinuria and acute mesangial injury induced by anti-Thy1. 1 monoclonal antibody[J]. Nephron Exp Nephrol,2005,99:e121.
[22]  王巍巍,张金元.丹酚酸B对马兜铃酸诱导的HK-2细胞TGF-β1与p38MAPK表达的影响[J].中国中西医结合肾病杂志,2010,11(8):673.
[23]  张莹,王荣,王群,等.益肾活血汤通过p38MAPK信号途径调控系膜细胞纤连蛋白及Ⅳ型胶原的研究[J].山东大学学报:医学版,2009,47(9):66.
[24]  Wang J P,Huang H Q,Liu P Q,et al. Inhibition of phosphorylation of p38 MAPK involved in the protection of nephropathy by emodin in diabetic rats[J]. Eur J Pharmacol,2006,553:297.
[25]  Liu W H,Tang F T,Deng Y H,et al. Berberine reduces fibronectin and collagen accumulation in rat glomerular mesangial cells cultured under high glucose condition[J]. Mol Cell Biochem,2009,325:99.
[26]  Ma F Y,Sachchithananthan M,Flanc R S,et al. Mitogen activated protein kinases in renal fibrosis[J]. Front Biosci,2009,1:171.
[27]  张新志,黄迪,吴锋. TGF-β1/p38MAPK通路对肾间质纤维化影响及抗纤灵冲剂干预机制的实验研究[J].中华中医药杂志,2011,26(2):245.
[28]  Zhang Y W,Xie D,Xia B,et al. Suppression of transforming growth factor-beta1 gene expression by Danggui Buxue Tang,a traditional Chinese herbal preparation,in retarding the progress of renal damage in streptozotocin-induced diabetic rats[J]. Horm Metab Res,2006,38:82.
[29]  Xu H Q,Hao H P. Effects of iridoid total glycoside from cornus officinalison prevention of glomerular overexpression of transforming growth factor beta1 and matrixes in an experimental diabetes model[J]. Biol Pharm Bull,2004,27:1014.
[30]  万毅刚,孙伟.清水不二雄,等.雷公藤多苷对不可逆性肾小球硬化模型系膜损伤的抑制作用[J].中国中药杂志,2005,30(5):361.
[31]  向少伟,王小琴,唐庆.肾安提取液对糖尿病小鼠肾脏TGF-β1和p38MAPK表达的影响[J].时珍国医国药,2011,22(2):314.
[32]  Baud L,Ardaillou R. Tumor necrosis factor in renal injury [J]. Miner Electrolyte Metab,1995,21:336.
[33]  孙艳玲,刘先义.参附注射液对肾缺血再灌注损伤大鼠p38MAPK、TNF-α表达的影响 [J].武汉大学学报:医学版,2006,27(3):385.
[34]  徐庆连,蔡晨,李国辉.川芎嗪对严重烫伤大鼠早期肾脏p38MAPK、TNF-α、超微结构变化的影响[J].安徽医学,2009,30(6):593.
[35]  Li L S,Liu Z H. Epidemiologic data of renal disease from a single unit in China:analysis based on 13,519 renal biopsies [J]. Kidney Int,2004,66:920.
[36]  王朝俊,万毅刚,罗浔阳,等.中药调节肾脏细胞信号通路的机制[J].中国中药杂志,2011,36(1):85.

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