Michaud J L,Boucher F,Melnyk A,et al.Sim1 haploinsufficiency causes hyperphagia,obesity and reduction of the paraventricular nucleus of the hypothalamus[J].Human Molecular Genetics,2001,10(14):1465-1473.
[2]
Holder J L,Zhang L,Kublaoui B M,et al.Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat in mice[J].American Journal of Physiology-Endocrinology and Metabolism,2004,287(1):E105-E113.
[3]
Tolson K P,Gemelli T,Gautron L,et al.Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin expression[J].The Journal of Neuroscience:the Official Journal of the Society for Neuroscience,2010,30(10):3803-3812.
[4]
Xi D,Gandhi N,Lai M,et al.Ablation of Sim1 neurons causes obesity through hyperphagia and reduced energy expenditure[J].PLoS One,2012,7(4):e36453.
[5]
Ramachamdrappa S,Raimondo A,Cali AMG,et al.Rare variants in single-minded 1 (SIM1) are associated with sever obesity[J].Journal of Clinical Investigation,2013,123(7):3042-3050.
Chen Z,Zhao X F,Hao Z,et al.Molecular characteristics of porcine SIM1 gene and its variants assiciation with carcass and meat quality traits[J].Journal of Animal and Veterinary Advances,2011,10(4):495-501.
[8]
Kublaoui B M,Holder J,Tolson K P,et al.SIM1 overexpression partially rescues agouti yellow and diet-induced obesity by normalizing food intake[J].Endocrinology,2006,147(10):4542-4549.
[9]
Xu Y Z,Wu Z F,Sun H,et al.Glutamate mediates the function of melanocortin receptor 4 on Sim1 neurons in body weight regulation[J].Cell Metabolism,2013,18(6):860-870.
[10]
Michaud J L,Rosenquist T,May N R,et al.Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1[J].Genes & Development,1998,12(20):3264-3275.
[11]
Ahmed M U,Cheng L,Dietrich S.Establishment of the epaxial-hypaxial boundary in the avian myotome[J].Developmental Dynamics:an Official Publication of the American Association of Anatomists,2006,235(7):1884-1894.
[12]
Eaton J L,Glasgow E.The zebrafish bHLH PAS transcriptional regulator,single-minded 1 (sim1),is required for isotocin cell development[J].Developmental Dynamics,2006,235(8):2071-2082.
Coumailleau P,Duperz D.Sim1 and Sim2 expression during chick and mouse limb development[J].The International Journal of Developmental Biology,2009,53:149-157.
[15]
Stipursky J,Francis D,Gomes F C.Activation of MAPK/PI3K/SMAD pathways by TGF-β(1) controls differentiation of radial glia into astrocytes in vitro[J].Developmental Neuroscience,2012,34(1):68-81.
[16]
Marsich E,Vetere A,Di Piazza M,et al.The PAX6 gene is activated by the basic helix-loop-helix transcription factor NeuroD/BETA2[J].The Biochemical Journal,2003,376(Pt 3):707-715.
[17]
Lefterova M I,Lazar M A.New developments in adipogenesis[J].Trends in Endocrinology and Metabolism,2009,20(3):107-114.
[18]
Czyzyk T A,Sikorski M A,Yang L,et al.Disruption of the RIIβ submit of PKA reverse the obesity syndrome of agouti lethal yellow mice[J].PNAS,2008,105(1):276-281.
[19]
Sarkar S,Legradi G,Lechan R M.Intracerebroventricular administration of α-melanocyte stimulating hormone increases phosphorylation of CREB in TRH-and CRH-producing neurons of the hypothalamic paraventricular nucleus[J].Brain Research,2002,945(1):50-59.
[20]
Tong Q,Tsai J,Tan G,et al.Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation[J].Molecular and Cellular Biology,2005,25(2):706-715.
[21]
Yamada M,Hashida T,Shibusawa N,et al.Genomic organization and promoter function of the mouse uncoupling protein 2 (UCP2) gene[J].FEBS Letters,1998,432(1-2):65-69.
