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Six1对骨骼肌发育和肌纤维类型转化的调控

DOI: 10.3969/j.issn.1006-267x.2015.07.004

Keywords: Six1,骨骼肌发育,肌纤维类型转化,表达谱

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Abstract:

Six1是近年来发现的骨骼肌发育和肌纤维类型转化的关键调控因子。Six1基因广泛表达于各动物不同组织中,尤其在骨骼肌中表达最丰富。Six1对骨骼肌的调控贯穿于动物胚胎期到出生后整个过程,调控着骨骼肌的发育、肌肉损伤修复和肌纤维类型转化。本文概述了Six1基因的发现、Six1蛋白的结构、Six1在不同动物中的表达谱以及Six1在骨骼肌发育、肌肉损伤修复、肌纤维类型转化中的作用。

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