The liver is a primary site for xenobiotics detoxification, and its metabolism is readily altered by toxicity. The kidney is a common target for toxic xenobiotics due to its capacity to extract and concentrate toxic substances by highly specialized cells. So, they are the target organs of sodium fluoride toxicity. The aim of this review is to highlight on hepatorenal oxidative stress and pathophysiological changes induced by treatment of experimental animals with sodium fluoride. Our review shows fluoride toxicosis caused an elevation in the serum activities of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase, acid phosphatase, and the level of total bilirubin, and reduction in the serum levels of total protein, albumin, and globulins, and serious histopathological changes in the hepaic tissues. Also, NaF administration caused increases in serum urea, creatinine, uric acid, sodium ions, and chloride ions levels and serious histopathological changes in the kidney tissues. Treatment of experimental animals with NaF induced oxidative stress in hepatic and renal tissues. It can be concluded that administration of sodium fluoride to experimental animals induced oxidative stress, serious hepatorenal histopathological changes, and disturbance in liver and kidney functions. So, human should be advised to decrease exposure to sodium fluoride to decrease the harmful effects of NaF on liver and kidney.
References
[1]
Gale, R.P., Spakes, R.S. and Golde, D.W. (1978) Bone Marrow Origin of Hepatic Macrophages (Kupffer Cells) in Humans. Science, 201, 937-938.
https://doi.org/10.1126/science.356266
[2]
Basha, S.K. and Rao, K.J. (2014) Sodium Fluoride Induced Histopathalogical Changes in Liver and Kidney of Albino Mice. Acta Chimica and Pharmaceutica Indica, 4, 58-62.
[3]
Emejulu, A.A., Alisi, C.S., Asiwe, E.S., Igwe, C.U., Nwogu, L.A. and Onwuliri, V.A. (2016) Renal and Hepato-Protective Effects of Irvingia gabonensis Juice on Sodium Fluoride-Induced Toxicity in Wistar Rats. Journal of Clinical Toxicology, 6, 296.
https://doi.org/10.4172/2161-0495.1000296
[4]
Choi, J.J., Moffett, B.S., McDade and Palazzo, D.L. (2011) Altered Gentamicin Serum Concentration in Obese Pediatric Patients. The Pediatric Infectious Disease Journal, 30, 347-349. https://doi.org/10.1097/INF.0b013e3181ff023e
[5]
Azab, A.E., Fetouh, F.A. and Albasha, M.O. (2014) Nephroprotective Effects of Curcumin, Rosemary and Propolis against Gentamicin Induced Toxicity in Guinea Pigs: Morphological and Biochemical Study. American Journal of Clinical and Experimental Medicine, 2, 28-35.
[6]
Guo-Ving, X., Sun, G. and Shun, Y. (2003) Oxidative Stress from Fluoride Induce Hepatotoxicity in Rats. Fluoride, 36, 25-29.
[7]
Dabrowaska, E., Letko, R. and Balunowska, M. (2006) Effect of Sodium Fluoride on the Morphological Picture of the Rat Liver Exposed to NaF in Drinking Water. Advances in Medical Sciences, 51, 91-95.
[8]
World Health Organization Regional Office for Europe (2000) Air Quality Guidelines for Europe. 2nd Edition, World Health Organization.
[9]
Mishra, P.C. and Arpradhan, K. (2007) Prevalence of Fluorosis among School Children and Cattle Population of Hirakud Town in Orissa. The Bioscan, 2, 31-36.
[10]
Okibe, F.G., Ekanem, E.J., Paul, E.D., Shallangwa, G.A., Ekwumemgbo, P.A., Sallau, M.S. and Abanka, O.C. (2010) Fluoride Content of Soil and Vegetables from Irrigation Farms on the Bank of River Galma, Zaria, Nigeria. Australian Journal of Basic and Applied Sciences, 4, 779-784.
[11]
Lewandowska, A., Falkowska, L. and Jozwik, J. (2013) Factors Determining the Fluctuation of Fluoride Concentrations in PM10 Aerosols in the Urbanized Coastal Area of the Baltic Sea (Gdynia, Poland). Environmental Science and Pollution Research, 20, 6109-6118. https://doi.org/10.1007/s11356-013-1592-2
[12]
Shitaw, K.N. (2015) Studies on the Levels of Fluoride in Selected Spices Cultivated and Consumed in Ethiopia. Master of Science in Analytical Chemistry, Department of Chemistry, College of Natural Sciences, Addis Ababa Universtiy, Addis Ababa.
[13]
IPCS (2002) Fluorides. International Programme on Chemical Safety (Environmental Health Criteria 227), World Health Organization, Geneva.
[14]
Yadav, B. and Garg, A. (2014) Impact and Remedial Strategy of Fluoride in Ground Water—A Review. International Journal of Engineering Research and Applications, 4, 570-577.
[15]
Slooff, W., Eerens, H.C., Janus, J.A., Ros, J.P., Janssen, P.J., Knaap, A.G., Lagas, P., Matthijsen, A.J., Reijnders, H.F., Struijs, J. and van de Wiel, H.J. (1988) Basis Document Fluoriden. National Institute of Public Health and Environmental Protection, Bilthoven, Report No. 758474005.
[16]
US EPA (1985) Drinking Water Criteria Document on Fluoride. US Environmental Protection Agency, Office of Drinking Water, Washington DC, TR-823-5.
[17]
Fawell, J.K., Ohanian, E., Giddings, M., Toft, P., Magara, Y. and Jackson, P. (2004) Fluoride in Drinking-Water, Background Document for Development of WHO Guidelines for Drinking-Water Quality. 3rd Edition, World Health Organization, Geneva.
[18]
IPCS (1984) Fluorine and Fluorides. International Programme on Chemical Safety (Environmental Health Criteria 36), World Health Organization, Geneva.
[19]
Pehrsson, P.R., Patterson, K.Y. and Perry, C.R. (2011) The Fluoride Content of Select Brewed and Microwave-Brewed Black Teas in the United States. Journal of Food Composition and Analysis, 24, 971-975.
https://doi.org/10.1016/j.jfca.2010.12.013
[20]
Waugh, D.T., Potter, W., Limeback, H. and Godfrey, M. (2016) Risk Assessment of Fluoride Intake from Tea in the Republic of Ireland and Its Implications for Public Health and Water Fluoridation. International Journal of Environmental Research and Public Health, 13, 259. https://doi.org/10.3390/ijerph13030259
[21]
Al-Harbi, M.S., Hamza, R.Z. and Dwari, A.A. (2014) Ameliorative Effect of Selenium and Curcumin on Sodium Fluoride Induced Hepatotoxicity and Oxidative Stress in Male Mice. Journal of Chemical and Pharmaceutical Research, 6, 984-998.
[22]
Everett, E.T. (2011) Effects of Fluoride on the Formation of Teeth and Bones, and the Influence of Genetics. Journal of Dental Research, 90, 552-560.
https://doi.org/10.1177/0022034510384626
[23]
Tokalioglu, S., Kartal, S. and Sahin, U. (2004) Determination of Fluoride in Various Samples and Some Infusions using a Fluoride Selective Electrode. Turkish Journal Chemistry, 28, 203-211.
[24]
Shanthakumari, D., Srinivasalu, S. and Subramanian, S. (2004) Effect of Fluoride Intoxication on Lipid Peroxidation and Antioxidant Status in Experimental Rats. Toxicology, 204, 214-228. https://doi.org/10.1016/j.tox.2004.06.058
[25]
Akdogan, M., Kaleli, S., Yazar, H., Desdicioglu, R. and Yuvaci, H.U. (2016) Effect of High-Dose Fluoride on Antioxidant Enzyme Activities of Amniotic Fluid in Rats. Journal of the Pakistan Medical Association, 66, 435-438.
[26]
Buzalaf, C.P., Leite, A.D.L. and Buzalaf, M.A.R. (2015) Fluoride Metabolism. In: Preedy, V.R., Ed., Food and Nutritional Components in Focus No. 6, Fluorine: Chemistry, Analysis, Function and Effects, Royal Society of Chemistry, Chapter 4.
http://www.rsc.org
[27]
Buzalaf, M.A. and Whitford, G.M. (2011) Fluoride Metabolism. Monographs in Oral Science, 22, 20-36. https://doi.org/10.1159/000325107
[28]
Villa, A., Anabalon, M., Zohouri, V., Maguire, A., Franco, A.M. and Rugg-Gunn, A. (2010) Relationships between Fluoride Intake, Urinary Fluoride Excretion and Fluoride Retention in Children and Adults: An Analysis of Available Data. Caries Research, 44, 60-68. https://doi.org/10.1159/000279325
[29]
Chinoy, N.J. and Shah, S.D. (2004) Beneficial Effects of Some Antidotes in Fluoride and Arsenic Induced Toxicity in Kidney of Mice. Fluoride, 37, 151-161.
[30]
Dote, T., Kono, K., Usuada, K., Nishiura, H., Tagawa, T. and Shimahara, M. (2000) Pharmacokinetic Parameters in Rats with Acute Renal Damage Caused by Intravenous High Dose of Fluoride. Fluoride, 33, S9-S10.
[31]
Inam, F., Tahir, M., Lone, K.P. and Latif, W. (2015) Protective Effect of Vitamin E on Fluoride Induced Hepatotoxicity. Biomed, 31, 1-6.
[32]
Song, C., Fu, B., Zhang, J., Zhao, J., Yuan, M., Peng, W., Zhang, Y. and Wu, H. (2017) Sodium Fluoride Induces Nephrotoxicity via Oxidative Stress-Regulated Mitochondrial SIRT3 Signaling Pathway. Scientific Reports, 7, 672.
https://doi.org/10.1038/s41598-017-00796-3
[33]
Abdel-Wahab, W.M. (2013) Protective Effect of Thymoquinone on Sodium Fluoride-Induced Hepatotoxicity and Oxidative Stress in Rats. The Journal of Basic and Applied Zoology, 66, 263-270. https://doi.org/10.1016/j.jobaz.2013.04.002
[34]
Qujeq, D., Laghaie, B., Gholipour, A., Solimani, N. and Hassenzadeh, S. (2002) Effects of Sodium Fluoride on Total Serum Protein Levels and Transaminase Activity in Rats. Biochemical Pharmacology, 56, 169-172.
https://doi.org/10.1016/S0753-3322(02)00172-5
[35]
Chattopadhyay, A., Podder, S., Agarwal, S. and Bhattacharya, S. (2011) Fluoride-Induced Histopathology and Synthesis of Stress Protein in Liver and Kidney of Mice. Archives of Toxicology, 85, 327-335.
https://doi.org/10.1007/s00204-010-0588-7
[36]
Vasant, R.A. and Narasimhacharya, A.V.R.L. (2012) Ameliorative Effect of Tamarind Leaf on Fluoride-Induced Metabolic Alterations. Environmental Health and Preventive Medicine, 17, 484-489. https://doi.org/10.1007/s12199-012-0277-7
[37]
Ismail, H.A., Hamza, R.Z. and El-Shenawy, N.S. (2014) Potential Protective Effects of Blackberry and Quercetin on Sodium Fluoride-Induced Impaired Hepato-Renal Biomarkers, Sex Hormones and Hematotoxicity in Male Rats. Journal of Applied Life Sciences International, 1, 1-16. https://doi.org/10.9734/JALSI/2014/12057
[38]
Bouasla, A., Bouasla, I., Boumendjel, A., El Feki, A. and Messarah, M. (2014) Hepatoprotective Role of Gallic Acid on Sodium Fluoride-Induced Liver Injury in Rats. International Journal of Pharmaceutical Sciences Review and Research, 29, 14-18.
[39]
Kaczor, J.J., Ziolkowski, W., Popinigis, J. and Tarnopolsky, M. (2005) Anaerobic and Aerobic Enzyme Activities in Human Skeletal Muscle from Children and Adults. Pediatric Research, 57, 331-335.
https://doi.org/10.1203/01.PDR.0000150799.77094.DE
[40]
Heidenreich, O., Neininger, A., Schratt, G., Zinck, R., Cahill, M.A. and Engel, K. (1999) MAPKAP Kinase 2 Phosphorylates Serum Response Factor in Vitro and in Vivo. The Journal of Biological Chemistry, 274, 14434-14443.
https://doi.org/10.1074/jbc.274.20.14434
[41]
Kant, V., Srisvastave, A.K., Verma, P.K. and Raina, R. (2009) Alteration in Biochemical Parameters during Sub-Acute Toxicity of Fluoride Alone and in Conjunction with Aluminium Sulfate in Goats. Biological Trace Element Research, 130, 20-30. https://doi.org/10.1007/s12011-008-8311-8
[42]
Giri, D.K., Ghosh, R.C., Kashyap, D.K., Dewangan, G. and Maiti, S.K. (2015) Haemato-Biochemical Alterations in Subacute Oral Toxicity of Sodium Fluoride in Wistar Rats. Journal of Animal Research, 5, 595-598.
https://doi.org/10.5958/2277-940X.2015.00100.X
[43]
Lu, Y., Luo, Q., Cui, H., Deng, H., Kuang, P., Liu, H., Fang, J., Zuo, Z., Deng, J., Li, Y., Wang, X. and Zhao, L. (2017) Sodium Fluoride Causes Oxidative Stress and Apoptosis in the Mouse Liver. Aging, 9, 1623-1639.
[44]
Mohammed, I.A. and Al-Okaily, B.N. (2017) Effect of Sodium Fluoride on Liver Functions of Rats and Amelioration by CoQ10. Journal of Entomology and Zoology Studies, 5, 887-893.
[45]
Yamaguti, P.Y., Simőes, A., Ganzerla, E., Souza, D.N., Nogueira, F.N. and Nicolau, J. (2013) Effects of Single Exposure of Sodium Fluoride on Lipid Peroxidation and Antioxidant Enzymes in Salivary Glands of Rats. Oxidative Medicine and Cell Longevity, 2013, Article ID: 674593. https://doi.org/10.1155/2013/674593
[46]
Jha, A., Shah, K. and Verma, R. (2012) Effects of Sodium Fluoride on DNA, RNA and Protein Contents in Liver of Mice and Its Amelioration by Camellia Sinensis. Acta Poloniae Pharmaceutica. Drug Research, 69, 551-555.
[47]
Sauerheber, R. (2013) Physiological Conditions Affect Toxicity of Ingested Industrial Fluoride. Journal of Environmental and Public Health, 2013, Article ID: 439490. https://doi.org/10.1155/2013/439490
[48]
Nehru, B. and Anand, P. (2005) Oxidative Damage Following Chronic Aluminum Exposure in Adult and Pup Rat Brains. Journal of Trace Elements in Medicine and Biology, 19, 203-208. https://doi.org/10.1016/j.jtemb.2005.09.004
[49]
Yılmaza, B.O. and Erkana, M. (2015) Effect of Vitamin C on Sodium Fluoride-Induced Oxidative Damage in Sertoli Cells. Fluoride, 48, 241-251.
[50]
Barbier, O., Mendoza, L.A. and DelRazo, L.M. (2010) Molecular Mechanisms of Fluoride Toxicity. Chemico-Biological Interactions, 188, 319-333.
https://doi.org/10.1016/j.cbi.2010.07.011
[51]
Atmaca, N., Atmaca, H.T., Kanici, A. and Anteplioglu, T. (2014) Protective Effect of Reveratol on Sodium Fluoride-Induced Oxidative Stress, Hepatotoxicity and Neurotoxicity in Rats. Food and Chemical Toxicology, 70, 191-197.
https://doi.org/10.1016/j.fct.2014.05.011
[52]
Shashi, A. and Thaparb, S.P. (2000) Histopathology of Fluoride-Induced Hepatotoxicity in Rabbits. Fluoride, 34, 34-42.
[53]
Hamza, R.Z., El-Shenawy, N.S. and Ismail, H.A.A. (2015) Protective Effects of Blackberry and Quercetin on Sodium Fluoride-Induced Oxidative Stress and Histological Changes in the Hepatic, Renal, Testis and Brain Tissue of Male Rat. Journal of Basic and Clinical Physiology and Pharmacology, 26, 237-251.
[54]
Bouaziz, H., Soussia, L., Guermazi, F., Zeghal, N. and Tunisia, S. (2005) Fluorideinduced Thyroid Proliferative Changes and Their Reversal in Female Mice and Their Pups. Fluoride, 38, 207-714.
[55]
Samanta, A., Bandyopadhyay, B. and Das, N. (2016) Fluoride Intoxication and Possible Changes in Mitochondrial Membrane Microviscosity and Organ Histology in Rats. International Journal of Scientific Research, 5, 42-45.
[56]
Ahmad, K.R., Noor, S., Jabeen, S., Nauroze, T., Kanwal, M.A., Raees, K. and Tahir, A. (2017) Amelioration by Jambul Fruit Extract of Fluoride Induced Hepato-Nephronal Histopathologies and Impaired Neuromotor Capacity in Mice. Fluoride, 50, 2-14.
[57]
Halliwell, B. and Guttteridge, J.M. (2007) Free Radicals in Biology and Medicine. Oxford University Press, Clarendon, Oxford, 221-238.
[58]
Anane, R. and Creppy, E.E. (2001) Lipid Peroxidation as Pathway of Aluminium Cytotoxicity in Human Skin Fibroblast Cultures: Prevention by Superoxide Dismutase + Catalase and Vitamins E and C. Human & Experimental Toxicology, 20, 477-481. https://doi.org/10.1191/096032701682693053
[59]
Chen, T., Cui, H., Cui, Y., Bai, C., Gong, T. and Peng, X. (2011) Cell-Cycle Blockage Associated with Increased Apoptotic Cells in the Thymus of Chickens Fed on Diets High in Fluorine. Human & Experimental Toxicology, 30, 685-692.
https://doi.org/10.1177/0960327110379022
[60]
Luo, Q., Cui, H., Peng, X., Fang, J., Zuo, Z., Deng, J., Liu, J. and Deng, Y. (2013) Intestinal IgA+ Cell Numbers as Well as IgA, IgG, and IgM Contents Correlate with Mucosal Humoral Immunity of Broilers during Supplementation with High Fluorine in the Diets. Biological Trace Element Research, 154, 62-72.
https://doi.org/10.1007/s12011-013-9713-9
[61]
Kuang, P., Deng, H., Cui, H., Chen, L., Fang, J., Zuo, Z., Deng, J., Wang, X. and Zhao, L. (2017) Sodium Fluoride (NaF) Causes Toxic Effects on Splenic Development in Mice. Oncotarget, 8, 4703-4717. https://doi.org/10.18632/oncotarget.13971
[62]
Thangapandiyan, S. and Miltonprabu, S. (2013) Epigallocatechin Gallate Effectively Ameliorates Fluoride-Induced Oxidative Stress and DNA Damage in the Liver of Rats. Canadian Journal of Physiology and Pharmacology, 91, 528-537.
https://doi.org/10.1139/cjpp-2012-0347
[63]
Liang, Q., Sheng, Y., Jiang, P., Ji, L., Xia, Y., Min, Y. and Wang, Z. (2011) The Gender-Dependent Difference of Liver GSH Antioxidant System in Mice and Its Influence on Isoline-Induced Liver Injury. Toxicology, 280, 61-69.
https://doi.org/10.1016/j.tox.2010.11.010
[64]
Chinoy, N., Sharma, A., Patel, T., Memon, R., Dd, J. and Ahmedabad (2004) Recovery from Fluoride and Aluminium Induced Free Radical Liver Toxicity in Mice. Fluoride, 37, 257-263.
[65]
Kumar, A., Sharma, S.K. and Vaidyanathan, S. (1988) Results of Surgical Reconstruction in Patients with Renal Failure Owing to Ureteropelvic Junction Obstruction. Journal of Urology, 140, 484-486.
https://doi.org/10.1016/S0022-5347(17)41697-1
[66]
Zhan, X.A., Wang, M., Xu, Z.R. and Li, J.-X. (2006) Toxic Effects of Fluoride on Kidney Function and Histological Structure in Young Pigs. Fluoride, 39, 22-26.
[67]
Al-Harbi, M.S., Hamza, R.Z. and Dwari, A.A. (2014) Sodium Fluoride Induced Antioxidant Defense Impairment and Impaired Renal Biomarkers and the Ameliorative Role of Selenium and Curcumin in Male Mice. Asian Pacific Journal of Tropical Disease, 4, S990-S997. https://doi.org/10.1016/S2222-1808(14)60771-4
[68]
Shashi, A., Singh, J.P. and Thapar, S.P. (2002) Toxic Effects of Fluoride on Rabbit Kidney. Fluoride, 35, 38-50.
[69]
Poesina, N.D., Balalau, C., Nimigean, V.R., Nimigean, V., Ion, I., Baconi, D. and Poesina, V.B. (2014) Histopathological Changes of Renal Tissue Following Sodium Fluoride Administration in Two Consecutive Generations of Mice. Correlation with the Urinary Elimination of Fluoride. Romanian Journal of Morphology and Embryology, 55, 343-349.
[70]
Shashi, A. and Kaur, J. (2017) Attenuation of Fluoride-Induced Nephrotoxicity in Rats by Leaf Extract of Punarnava (Boerhaavia diffusa L.). European Academic Research, 5, 3805-3822.
[71]
Shimizu, S., Eguchi, Y., Kamiike, W., Waguri, S., Uchiyama, Y., Matsuda, H. and Tsujimoto, Y. (1996) Retardation of Chemical Hypoxiainduced Necrotic Cell Death by Bcl-2 and ICE Inhibitors: Possible Involvement of Common Mediators in Apoptotic and Necrotic Signal Transductions. Oncogene, 12, 2045-2050.
[72]
Chagnac, A., Weinstein, T., Korzets, A., Ramadan, E. and Hirsch, J. (2000) Glomerular Hemodynamics in Severe Obesity. American Journal of Physiology-Renal Physiology, 278, F817-F822. https://doi.org/10.1152/ajprenal.2000.278.5.F817
[73]
Chen, H.M., Liu, Z.H., Zeng, C.H., Li, S.J., Wang, Q.W. and Li, L.S. (2006) Podocyte Lesions in Patients with Obesity-Related Glomerulopathy. American Journal of Kidney Diseases, 48, 772-779. https://doi.org/10.1053/j.ajkd.2006.07.025
[74]
Salam, Z. and Agha, A. (2007) Histological, Histochemical and Ultrastructural Studies on the Kidney of Rats after Administration of Monosodium Glutamate. Al-Aqsa University, Gaza, 21-40.
[75]
Inkielewicz-Stepniak, I. and Knap, N. (2012) Effect of Exposure to Fluoride and Acetaminophen on Oxidative/Nitrosative Status of Liver and Kidney in Male and Female Rats. Pharmacological Reports, 64, 902-911.
https://doi.org/10.1016/S1734-1140(12)70885-X
[76]
Bharti, V.K., Srivastava, R.S., Kumar, H., Bag, S., Majumdar, A.C., Singh, G., Pandi-Perumal, S.R. and Brown, G.M. (2014) Effects of Melatonin and Epiphyseal Proteins on Fluoride-Induced Adverse Changes in Antioxidant Status of Heart, Liver, and Kidney of Rats. Advances in Pharmacological Sciences, 2014, Article ID: 532969. https://www.hindawi.com/journals/aps/2014/532969
https://doi.org/10.1155/2014/532969
[77]
Song, Y., Wang, J.C., Xu, H., Du, Z.W., Zhang, G.Z., Selim, H.A., Li, G.S., Wang, Q. and Gao, Z.L. (2013) Fluorosis Caused Cellular Apoptosis and Oxidative Stress of Rat Kidneys. Chemical Research in Chinese Universities, 29, 263-269.
https://doi.org/10.1007/s40242-013-2430-2
[78]
Song, G.H., Gao, J.P., Wang, C.F., Chen, C.Y., Yan, X.Y., Guo, M., Wang, Y. and Huang, F.B. (2014) Sodium Fluoride Induces Apoptosis in the Kidney of Rats through Caspase-Mediated Pathways and DNA Damage. Journal of Physiology and Biochemistry, 70, 857-868. https://doi.org/10.1007/s13105-014-0354-z
[79]
Bano, M. and Bhatt, D.K. (2007) Neuroprotective Role of a Novel Combination of Certain Antioxidants on Lindane (γ-HCH) Induced Toxicity in Cerebrum of Mice. Research Journal of Agriculture and Biological Sciences, 3, 664-669.
[80]
Garcia-Montalvo, E.A., Reyes-Perez, H. and Del Razo, L.M. (2009) Fluoride Exposure Impairs Glucose Tolerance via Decreased Insulin Expression and Oxidative Stress. Toxicology, 263, 75-83. https://doi.org/10.1016/j.tox.2009.06.008
