BKCa通道的力敏感性

大电导钙激活的钾通道（large-conductance Ca2+-activated K+channel, BKCa）可被应力激活，表现出力敏感性，进而参与应力对细胞功能的调控。然而，不同类型的细胞其BKCa通道响应于不同的力学加载方式，其表达或活性的变化不同。相应地，其被应力激活的机制也不同，有的通过Ca2+浓度的升高被激活，有的则通过膜脂或细胞骨架的变化被激活。从BKCa通道力敏感性的分子结构基础、BKCa通道力敏感性的表现、应力激活BKCa通道的机制3个方面概述BKCa通道力敏感性的相关研究进展。
Large-conductance Ca2+-activated K+ (BKCa) channels, activated by stress, exhibit mechanosensitivity and are involved in stress-regulated cellular function. For different types of cells, they will have different expression and activity changes due to their BKCa channels responding to different stress patterns. Correspondingly, the mechanism underling channel activation behaves differently, which is activated by the elevation in Ca2+ concentration or changes in membrane bilayer and cytoskeleton. In this review, the research progress in mechanosensitivity of BKCachannels was summarized from 3 aspects, including its molecular structure basis, manifestation and stress activation mechanism.