利塞膦酸盐对磷硅酸钙理化及生物性能的影响

摘要 将利塞膦酸盐(0.5%和1.0%)与含有磷硅酸钙的骨水泥粉末混合后进行水化反应，测定骨水泥固化时间及抗压强度，并分析其载药前后的微观结构变化.通过细胞毒性与基因表达水平检测分析了骨水泥的生物性能.结果表明:在0.5%药物水平下，骨水泥促进成骨细胞增殖与分化效果最佳.药物可延缓骨水泥固化，但骨水泥的气孔率会随之降低且晶体结构会更加紧密.载有利塞膦酸的磷硅酸钙骨水泥具有与松质骨相似的力学强度及良好的生物相容性，作为骨组织修复材料具有很好的应用价值.
Abstract：Risedronate (0.5% and 1.0%) was mixed with bone cement powder containing calcium phosphate silicate for hydration reaction. The curing time and compressive strength of bone cement were measured and the microsturctural changes before and after drug loading were analyzed. The biological properties of bone cement were analyzed by detection of cytotoxicity and gene expression levels. The results showed that the best proliferation and differentiation of osteoblasts were obtained at 0.5% drug level.The drug can delay the curing of bone cement， but the porosity of bone cement decrease and the crystal structure become tighter.The calcium phosphate silicate cement containing risedronate acid has good biocompatibility and the mechanical strength similar to cancellous bone， which is prosperous in the application of a bone tissue repair material.