A synthesis of nanochitosan from Bombyx mori
chitosan with particle sizes of 20 - 100 nm was carried out. The antibacterial
and immunological properties of synthesized nanochitosan were first studied. It
was revealed that preparations based on nanochitosan have pronounced
antibacterial activity, and are also able to significantly increase the immune
response of the living system.
References
[1]
Muzzarelli, R.A.A. and Muzzarelli, C. (2002) Chitosan in Pharmacy and Chemistry, Atec, Italy.
[2]
Schuetz, Y.B., Gurny, R. and Jordan, O. (2008) A Novel Thermoresponsive Hydrogel Based on Chitosan. European Journal of Pharmaceutics and Biopharmaceutics, 68, 19-25. https://doi.org/10.1016/j.ejpb.2007.06.020
[3]
Fischer, S., Foerg, C., Merkle, H.P. and Gander, B. (2004) Chitosan Coated Plga-Microspheres—A Modular System for Targeted Drug Delivery. European Cells and Materials, 7, 11-12.
[4]
Andrianova, I.E. (2001) New Advances in the Study of Chitin and Chitosan: Mater. VI International Conference, Moscow-Schelkovo, VNIRO, Moscow, 22-24 October 2001, S.126-S.127.
[5]
Bygchkov, A.V., Byghkova, V.M. and Krivosheina, L.I. (2003) New Advances in the Study of Chitin and Chitosan: Mater. VII International Conference, St. Petersburg-Repino, VNIRO, Moscow, 15-18 September 2003, S156-S157.
[6]
Jeon, Y.J., Park, P.J. and Kim, S.K. (2001) Antimicrobial Effect of Chitooligosaccharides Produced by Bioreactor. Carbohydrate Polymers, 44, 71-76.
https://doi.org/10.1016/S0144-8617(00)00200-9
[7]
Qi, L.L., Xu, Z.R., Jiang, X., Hu, C. and Zou, X.F. (2004) Preparation and Antibacterial Activity of Chitosan Nanoparticles. Carbohydrate Research, 339, 2693-2700.
https://doi.org/10.1016/j.carres.2004.09.007
[8]
Rabea, E.I., et al. (2003) Chitosan as Antimicrobial Agent: Applications and Mode of Action. Biomacromolecules, 4, 1457-1465. https://doi.org/10.1021/bm034130m
[9]
Ravi Kumar, M.N.V. (2000) A Review of Chitin and Chitosan Applications. Reactive &Functional Polymers, 46, 1-27.
https://doi.org/10.1016/S1381-5148(00)00038-9
[10]
Milusheva, R.Yu, Rakhmanova, V.N., Inoyatova, F.K. and Rashidova, S.Sh. (2012) Synthesis of Chitosan Derivatives of Bombyx mori and Their Use in Diseases of Various Etiologies. XI International Conference of Modern Prospects in the Study of Chitin and Chitosan, Murmansk, June 25-30 2012, 69-72.
[11]
Milusheva, R.Yu, Ibragimov, K.S. and Rashidova, S.Sh. (2014) Bioactive Polymers from Waste from Silk Production. XII International Conference of Current Prospects in the Study of Chitin and Chitosan, (RosHit, Perm, Tentorium Hall.), 230-232.
[12]
Vasquez, D., Milusheva, R., Baumann, P., Constantin, D., Chami, M. and Palivan, C. (2014) The Amine Content of PEGylated Chitosan Bombyx mori Nanoparticles Acts as a Trigger for Protein Delivery. Langmuir, 30, 965-975.
https://doi.org/10.1021/la404558g
[13]
Millusheva, R.Yu, Pirniyazov, К.К. and Rashidova, S.Sh. (2016) Purification of Chitosan Bombyx mori. Journal of Bulletin of Tver State University, Series: Chemistry, No. 2, 119-124.
[14]
Millusheva, R.Yu. and Rashidova, S.Sh. (2017) Bioactive Properties of Na-nochitosan Bombyx mori. Polymer Science, Series C, 59, 29-34.
https://doi.org/10.1134/S1811238217010088
[15]
Rashidova, S.Sh. and Millusheva, R.Yu. (2009) Chitin and Chitosan Bombyx mori. Synthesis, Properties and Application. Tashkent, FAN, 246.
[16]
Millusheva, R.Yu., Muhamedov, I.M., Batirbekov, A.A. and Rashidova, S.Sh. (2016) Nanochitosan Bombyx mori: Synthesis and Aspects of Biomedical Application. Oral Report at the XIII International Conference of Modern Prospects in the Study of Chitin and Chitosan, (RosHit-2016).
[17]
Clemens, J.A., Klein, C.P., Vriesde, R.C., Rozing, P.M. and de Groot, K. (1998) Healing of Large (2mm) Gaps around Calcium Phosphate-Coated Bone Implants: A Study in Goats with a Follow-up of 6 Months. Journal of Biomedical Materials Research, 40, 341-349.
https://doi.org/10.1002/(SICI)1097-4636(19980605)40:3<341::AID-JBM1>3.0.CO;2-F
[18]
Moroni, A., Aspenberg, P., Toksvig-Larsen, S., Falzarano, G. and Giannini, S. (1998) Enhanced Fixation with Hydroxyapatite Coated Pins. Clinical Orthopaedics and Related Research, 346, 171-177. https://doi.org/10.1097/00003086-199801000-00024
[19]
Ban, S. and Maruno, S. (1993) Deposition of Calcium Phosphate on Titanium by Electrochemical Process in Simulated Body Fluid. Japanese Journal of Applied Physics, 32, 1577-1580. https://doi.org/10.1143/JJAP.32.L1577
[20]
Habibovic, P., Barrère, F., van Blitterswijk, C.A., de Groot, K. and Layrolle, P. (2002) Biomimetic Hydroxyapatite Coating on Metal Implants. Journal of the American Ceramic Society, 85, 517-522.
https://doi.org/10.1111/j.1151-2916.2002.tb00126.x
[21]
Lahiji, A., Sohrabi, A., Hungerford, D.S. and Frondoza, C.G. (2000) Chitosan Supports the Expression of Extracellular Matrix Proteins in Human Osteoblasts and Chondrocytes. Journal of Biomedical Materials Research, 51, 586-595.
https://doi.org/10.1002/1097-4636(20000915)51:4<586::AID-JBM6>3.0.CO;2-S
