The Impact of Microenvironment on the Synovial Sarcoma Transcriptome

Synovial sarcomas are comprised of a high percentage of tumor cells. a Photomicrographs of H&E histology examples of monophasic (MSS, left) and biphasic (BSS, right) SS18-SSX-induced synovial sarcomas from Myf5Cre-induced mice. b Photomicrographs following immunohistochemistry against GFP in MSS (left) and BSS (right) synovial sarcomas. c Pie charts demonstrating the percentage of GFP+ cells stained by IHC and counted in MSS (left) and BSS (right) mouse tumors. d Example flow cytometry of mouse MSS (left) and BSS (right) for intrinsic GFP signaling in tumor cells and E-cadherin-APC. (Magnification bars =50 μm