E4orf1 protein reduces the need for endogenous insulin

Mean？±？SD. a GTT was performed in E4orf1 transgenic and non-transgenic mice (after 4？h of starvation) by injecting D-glucose (1.5？mg/kg of body weight) intra-peritoneally. Blood glucose was determined at 0, 15, 30, 60, and 120？min post-glucose load shows significantly faster glucose clearance in E4orf1-expressing mice. b Body weight did not differ significantly between the two groups. The hyperinsulinemic–euglycemic clamp studies performed on these mice do not show any difference in c fasting blood glucose (mg/dL), d glucose infusion rate, or e plasma insulin (ng/mL). The groups were compared using t-test, *p？≤？0.0