Ocular Mucous Membrane Pemphigoid: Current State of Pathophysiology, Diagnostics and Treatment

In the injury phase, autoantibodies are directed against conjunctival BM antigens, such as BP180, laminin 332 (laminin 5), collagen VII, and α6β4 integrin [17]. The activated T cells generate specific B-cell clones, and these clones produce circulating autoantibodies (IgG and IgA) that bind to the specific BMZ component, initiate a type 2 hypersensitivity reaction, and activate the complement cascade (C3) [15]