Preclinical Safety Evaluation of Ophthalmic Viscosurgical Devices in Rabbits and a Novel Mini-Pig Model

Rabbit pyrogenicity study conducted on HEALON5 PRO OVD demonstrates HEALON OVD products are non-pyrogenic. Three separate studies were conducted on three different lots of HEALON5 PRO OVD. Each study was conducted with n？=？4, one control “C” and three experimental animals (？ 1, ？ 2, ？ 3). Temperatures were taken every 30 min for a total of 3 h. Bars from left to right in each grouping are baseline, 1 h, 1.5 h, 2 h, 2.5 h, and 3 h. Data from all three studies are graphed togethe