Bullous Systemic Lupus Erythematosus in a Pregnant Woman associated with Lupus Nephritis Responding to Dapsone

Bullous systemic lupus erythematosus (b-SLE) is a rare blistering condition with a distinctive combination of clinical, histological and immune pathologic features that together constitute a unique bullous disease phenotype. It is often associated with autoimmunity to type VII collagen. Here we report a 23 years old woman with an 11-week pregnancy diagnosed with lupus six months prior to consultation who presented with b-SLE associated with renal disease. Rapid resolution of the blisters occurred following treatment with dapsone. This is the first report of b-SLE during pregnancy associated with lupus nephritis in English literature