The Influence of Abnormal Mother to Infant Thyroid Function, Early Intervention Treatment on the Compensation for Mental Retardation

Objective: To observe the hyperthyroidism and hypothyroidism patients with pregnancy after production, the baby’s thyroid function changes, the baby's mental abnormality, compensation for the children with intellectual disabilities and early intervention after treatment. Methods: In this study, 151 pregnant women with abnormal thyroid function from Department of Endocrinology in Jilin Central Hospital between 2010-2016, these women in the G12 and G24 were measured FT3, FT4, TSH, TPO, TG-ab, the babies at birth, 6 months, 12 months, examine their thyroid function, exercise and intelligence score respectively. Results: Hyperthyroidism group and hypothyroidism group of pregnant women after intervention treatment of G12 and G24, thyroid function tends to normal, there were no significant differences in FT3, FT4 and TSH levels. TSH was significantly increased in the patients with hyperthyroidism group at birth, compared with the other two groups, P < 0.05, the difference was statistically significant. Comparison of the nerve intelligence development and motor scores of the pregnant women in each group MDI and PDI, the levels of MDI and PDI in the hyperthyroidism group were decreased, but the late rise was obvious, there was no significant difference between the groups. There was no significant difference in the development of thyroid and nerve intelligence and motor scores after early intervention in the healthy control group. Conclusion: The abnormal thyroid function of pregnant women can affect the thyroid function of offspring, so that the intelligence development of offspring is affected. Adverse pregnancy was significantly increased, timely intervention treatment of pregnant women with abnormal thyroid function and adjustment of sub generation, the intelligence score and the absolute value of the motor score can be increased, it shows compensative effect on mental retardation in their offspring