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Keywords: Thirty-six male Wistar rats, divided into six groups of six rats each, were assigned into diabetic and non-diabetic groups. Diabetes was induced in rats by single intraperitoneal administration of streptozotocin (65 mg/kg b.w.) and nicotinamide (110 mg/kg b.w.). The first two groups were normal and diabetic controls, whereas the other four diabetic groups were treated with water extracts of the medicinal plants, B. carterii (100 mg/kg b.w.) and C. rotundifolia (100 mg/kg b.w.), glibenclamide (5 mg/kg b.w.) and metformin (150 mg/kg b.w.). Body weight and serum glucose were measured on days 1, 7, 14, 21 and 28. Serum cholesterol and triglyceride levels were also measured.
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Objective: To evaluate the hypoglycemic activity of Boswellia carterii and Cissus rotundifolia in rats compared to that of glibenclamide and metformin as common oral hypoglycemic drugs.
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