Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis

？ Deletion of MyD88 or TLR4 in IMCs and/or CAFs leads to reduced intestinal tumorigenesis ？ The phenotype of the IMC-specific MyD88 mice is similar to the complete knockouts ？ MyD88？/？ IMCs show a reduced pro-tumorigenic and/or inflammatory gene expression profile ？ Human CAFs show upregulation of a similar MyD88-specific gene expression signatur